Inflammation Clinical Trial
Official title:
Effects of Severe Negative Energy Balance on Inflammation During a Simulated Military Operation
The effects of prolonged negative energy balance, commonly observed in sustained military training and combat operations, on systemic inflammatory responses has not been determined. To define the putative role of energy balance on inflammation and its downstream effects, we will conduct a controlled laboratory study that simulates extensive physiological stressors to determine if inflammation is exacerbated by underfeeding. This design will test the hypothesis that maintaining energy balance will attenuate systemic inflammation and its potential negative effects on whole-body metabolic homeostasis in response to physiological stressors.
Endurance exercise elicits skeletal muscle and systemic inflammation. Inflammation in
response to endurance exercise is normally attenuated with adequate rest and recovery as
skeletal muscle adapts with training. However, performing repeated bouts of prolonged and
unaccustomed, muscle damaging (i.e., eccentric loading) endurance exercise may be detrimental
to performance and limit the adaptive responses to exercise by diminishing the absorption of
key nutrients. Warfighters are commonly exposed to such exercise bouts during sustained
training and combat operations, the effects of which may be exacerbated by negative energy
balance. Therefore, to define the putative role of energy balance on systemic inflammation,
we will conduct a controlled laboratory study that simulates the physiological stressors
imposed during sustained military training and combat operations to determine if systemic
inflammation is exacerbated by underfeeding.
Twenty-six male, non-obese (body mass index 19.9-29.9 kg/m2), physically active adults will
be recruited to participate in a 32 d, longitudinal study. The study is comprised of four
sequential phases: 1) a 96 h testing period, 2) a 7 day recovery period (Recovery 1), 3) a
second, 96 h testing period, and 4) a 14 d recovery period (Recovery 2). During testing,
subjects will be randomized to consume either sufficient food (combat rations) to maintain
energy balance or will be provided a restricted amount of food to elicit severe negative
energy balance. Mineral absorption studies and will be conducted during each testing
condition, energy balance and energy negative balance. This design will test the hypothesis
that maintaining energy balance will attenuate systemic inflammation and its potential
negative effects on whole-body metabolic homeostasis in response to physiological stressors.
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