Infectious Disease Clinical Trial
Official title:
Etiology, Prevention, and Treatment of Neonatal Infections in the Community
The purpose of this study is to determine what are the major types of bacteria that cause newborn infections in the community in rural Bangladesh and whether providing an obstetric and neonatal care package will reduce neonatal deaths by 40%.
The study seeks answers to two questions:
1. What are the major bacterial pathogens responsible for serious neonatal infections in
the community in rural Bangladesh?
2. Can provision of a package of obstetric and neonatal care, including active surveillance
for serious neonatal illness and referral to hospital, and identification of barriers to
care-seeking and design of strategies to address them reduce neonatal mortality rates by
at least 40% compared to communities in which such services are not provided?
Despite significant decline in infant and child mortality rates in recent decades, neonatal
mortality rates remain unacceptably high. Of the 8 million infant deaths that occur worldwide
each year, approximately 4 million occur in the neonatal period.
Hence, the specific aims of the study include:
1. identifying the principal agents of serious bacterial infections in Bangladeshi neonates
in the community
2. evaluating the impact of introducing a package of essential obstetric and neonatal care
practices in the community, including identifying barriers to care-seeking and design of
strategies to address those barriers and
3. building capacity within Bangladesh by training Bangladeshi scientists in
epidemiological and microbiological techniques, clinical research methods and best
clinical practice through an on-going collaboration with Dhaka Shishu (Children)
Hospital and the International Centre for Diarrhoeal Disease Research, Bangladesh.
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