Improvement of Cardiovascular Autonomic Control. Clinical Trial
Official title:
Inspiratory Muscle Training: Effects on Blood Pressure, Heart Rate Variability and Functional Capacity in Hypertensive Patients.
The purpose of this study is to determine inspiratory muscle training effects on blood pressure, functional capacity and quality of life in hypertensive patients.
The interaction between respiratory function and cardiovascular system, as well as the
present alterations in these systems, due to diseases such as Hypertension, diabetes and
chronic heart failure, are the factors that potentially participate of the pathogenic frame
in these situations. Consequently, it is so related to reduction of functional capacity,
endothelial dysfunction of the sympathetic and parasympathetic cardiovascular control and
morphologic alterations on the skeletal muscles, including ventilatory muscles.
On the other hand, a proinflammatory state also participates of this dysfunction and reduced
function capacity situation. Cardiovascular risk factors, such as hypertension, increased
heart rate variability, diabetes and heart failure explain the occurrence of the majority of
cardiovascular events in the entire world and so in Brazil. Studies with experimental models
and in patients with cardiovascular diseases identified important inflammatory activity
associated to risk factors and preceding clinical events.
Inspiratory muscle training (IMT) shows consistent results in the improvement of functional
capacity in athletes, sedentary subjects, heart failure patients and in animals submitted to
an IMT model.
The study of alterations in cardiorespiratory interaction, functional capacity and
cardiovascular control mechanisms (sympathetic, parasympathetic by heart rate variability),
altogether, in hypertension, is a single opportunity to identify new pathogenic mechanisms
involved in the reduction of functional capacity as well as promote its quantification.
Therefore, the effects of IMT on these alterations are still not well understood. In this
way, the response to IMT is a complement to epidemiologic and clinical models, as potential
source of new possibilities in the research field.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT01643421 -
Effect of a Program of Deep Inspiration Combined to Expiratory Positive Airway Pressure in Asthmatic
|
N/A |