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'Optiflow + Duet' Interface' vs 'Standard' High Flow Nasal Cannula — OPTIMARF  

Hypoxemia Clinical Trial

Official title:
Physiological Effects of High Flow Oxygen Therapy Using 'Optiflow + Duet' Interface vs 'Standard' High Flow Nasal Cannula for Acute Respiratory Failure After Extubation. The OPTIMARF Study.

Clinical Trial Summary

High-flow nasal cannula (HFNC) therapy is increasingly used in the management of acute respiratory failure. Its clinical application has been largely investigated in chronic obstructive pulmonary disease (COPD) patients but only marginally in patients experiencing acute respiratory failure after extubation. Promising data have been published in vitro about new asymmetrical high flow nasal cannula, named 'Optiflow + DUET'. Positive airway pressure, that dynamically changes with breathing, and clearance of anatomical dead space are the key mechanisms of noninvasive respiratory support with nasal high flow. Pressure mainly depends on flow rate and nare occlusion. The hypothesis is that an increase in asymmetrical occlusion of the nares leads to an improvement in dead-space clearance resulting in a reduction in re-breathing and breathing work.

Clinical Trial Description

A prospective cross-over RCT on the effects of 'Optiflow + DUET' as compared to convetional symmetrical high flow cannula and Venturi mask. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05838326
Study type Interventional
Source University of Padova
Contact
Status Completed
Phase N/A
Start date May 8, 2023
Completion date July 30, 2023
View Details
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