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Antenatal Betamethasone and the Risk of Neonatal Hypoglycemia

Hypoglycemia Clinical Trial

Official title:
Antenatal Betamethasone and the Risk of Neonatal Hypoglycemia: It's All About Timing

Clinical Trial Summary

A single "supraphysiological" course of exogenous corticosteroids is recommended between 24-34 weeks' gestation to minimize the adverse sequelae associated with prematurity. The 24-hour profile of endogenous corticosteroids normally follows a diurnal rhythm with the highest serum level occurs between 5am-11am and nadir over 12 hours.

Clinical Trial Description

A retrospective study from January 2010 to December 2017. Eligible for analysis are: singleton pregnancies between 24 - 34 weeks' gestation who were given a single course of intramuscular betamethasone. Single course comprised of two separate doses of 12 mg given 24 hours apart. Each woman was allocated into one of the four pre-defined groups based on the time the intramuscular betamethasone was administered; Group 1 (5am-11am), group 2 (11am-5pm), group 3 (5pm-11pm) and group 4 (11pm-5am). The investigators hypothesized that exogenous corticosteroids given during the nadir state of endogenous corticosteroids activity could alter maternal and fetal glucose homeostasis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03702959
Study type Observational [Patient Registry]
Source Rambam Health Care Campus
Contact Yaniv Zipori, M.D
Phone +972 58 7966963
Email y_zipori@rambam.health.gov.il
Status Not yet recruiting
Phase
Start date October 1, 2018
Completion date March 1, 2020
View Details
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