Hypertension Clinical Trial
Official title:
A Randomized, 32 Week Double-blind, Parallel-group, Multicenter Study to Compare the Efficacy and Safety of Initiating Treatment With Combination (Aliskiren/Amlodipine) Therapy in Comparison With the Sequential add-on Treatment Strategies in Patients With Essential Hypertension
This study will compare the safety and efficacy of initial combination treatment with aliskiren + amlodipine to sequential add-on treatment strategies with aliskiren or amlodipine in patients with hypertension.
This study was designed to evaluate if patients with hypertension treated early with a
combination therapy would achieve better blood pressure (BP) control, than patients being
treated with a classical sequential add-on therapy.
The study compared the effects of the two treatment strategies: Treatment initiation on a
single compound, either with aliskiren or amlodipine, and then continuation with the
combination of both versus treatment initiation with the combination of aliskiren/amlodipine
and then continuation with the combination. The study also evaluated if the overall mean
sitting systolic blood pressure (msSBP)-lowering effect during the study, as well as the
change from baseline to study end in msSBP, are superior in the group having received
combination therapy from the beginning.
The study further evaluated the BP-lowering efficacy and tolerability of both treatment
strategies.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Diagnostic
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