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Clinical Trial Summary

Evaluation of the effect of FIXED triple anti-hypertensive therapy with losartan-amlodipin-HCTZ vs any free triple combination therapy chosen by the treating physician for patients with uncontrolled hypertension


Clinical Trial Description

Patients who have uncontrolled hypertension and who require triple therapy will be randomized to receive:

1. Fixed combination containing 3 anti-hypertensive drugs: losartan 100 mg + amlodipin 5 mg + hydrocholorothiazide 12.5 mg one tab/day

2. Or any other therapy decided by the treating physician containing three anti-hypertensive agents but supplied as "free" therapy, meaning supplied as 2 or 3 separate tablets Patients will have a baseline ambulatory blood pressure recording. The same recording will be repeated at 2 months of therapy.

We expect fixed triple combination to be more effective because the drugs used work synergistically together and the compliance will be higher ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03578042
Study type Interventional
Source Hotel Dieu de France Hospital
Contact Rabih R Azar, MD, MPH
Phone +9611615300
Email razar@usj.edu.lb
Status Recruiting
Phase Phase 4
Start date April 1, 2017
Completion date December 30, 2019

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