Hypertension Clinical Trial
Official title:
Effect of Fixed Triple Combination With Losartan-Amlodipin-HCTZ vs. Free Triple Combination on Blood Pressure Control
Evaluation of the effect of FIXED triple anti-hypertensive therapy with losartan-amlodipin-HCTZ vs any free triple combination therapy chosen by the treating physician for patients with uncontrolled hypertension
Patients who have uncontrolled hypertension and who require triple therapy will be randomized
to receive:
1. Fixed combination containing 3 anti-hypertensive drugs: losartan 100 mg + amlodipin 5 mg
+ hydrocholorothiazide 12.5 mg one tab/day
2. Or any other therapy decided by the treating physician containing three
anti-hypertensive agents but supplied as "free" therapy, meaning supplied as 2 or 3
separate tablets Patients will have a baseline ambulatory blood pressure recording. The
same recording will be repeated at 2 months of therapy.
We expect fixed triple combination to be more effective because the drugs used work
synergistically together and the compliance will be higher
;
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