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Clinical Trial Summary

The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase brain amyloid beta protein accumulation and affect memory and thinking ability in older adults. However, whether lowering blood pressure reduces brain amyloid beta protein and improves brain function is inconclusive.

The investigators hypothesize that treating high blood pressure alters brain pulsatility, which in turn reduces brain amyloid beta protein accumulation and improves brain structure and function.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03354143
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Wanpen Vongpatanasin, MD
Phone (214) 648-3180
Email Wanpen.Vongpatanasin@UTSouthwestern.edu
Status Recruiting
Phase Phase 2
Start date April 10, 2018
Completion date October 31, 2022

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