Clinical Trials Logo
NCT number NCT02913664
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Megha Sharma, BS
Phone 214-345-7134
Email MeghaSharma@texashealth.org
Status Recruiting
Phase Phase 2/Phase 3
Start date September 2016
Completion date September 2022

Clinical Trial Summary

Physical inactivity, high blood pressure and dyslipidemia are risk factors for Alzheimer's disease (AD) and vascular dementia. Importantly, these risk factors are modifiable with lifestyle changes, pharmacological treatment, or both. The rrAD study will determine effects of aerobic exercise training and intensive vascular risk reduction on cognitive performance in older adults who have high risk for AD.


Clinical Trial Description

Numerous lines of evidence suggest that interventions that confer therapeutic benefit for cardiovascular health are also associated with improvements in, or preservation of, cognitive function. Many researchers and health care providers believe "What's good for the heart is good for the brain." However, stronger scientific evidence is needed to prove this hypothesis. The rrAD study is a 4-arm, multicenter, randomized trial to assess effects of aerobic exercise training and intensive pharmacological reduction of vascular risk factors on cognitive performance in older adults who have high risk for AD, that is, those who have high blood pressure, family history of dementia or subjective memory complaints. Furthermore, rrAD will examine effects of exercise and vascular risk reduction on brain volume, perfusion, and neural network connectivity using magnetic resonance imaging (MRI).


Study Design


Related Conditions & MeSH terms


See also
  Status Clinical Trial Phase
Completed NCT03093532 - A Hypertension Emergency Department Intervention Aimed at Decreasing Disparities N/A
Not yet recruiting NCT03284099 - Bedtime ACEIs/ARBs Versus Morning ACEIs/ARBs for Reverting Non-dipping Hypertension Phase 4
Recruiting NCT03170752 - Implementing and Testing a Cardiovascular Assessment Screening Program (CASP) N/A
Recruiting NCT03266510 - Inspiratory Muscle Strength Training to Improve Blood Pressure and Physiological Function N/A
Completed NCT00508365 - Evaluation of Potential for Orthostatic Hypotension in Elderly Hypertensives Phase 1
Completed NCT00382564 - Magnetic Resonance Angiography to Diagnose Atherosclerotic Disease N/A
Recruiting NCT03249753 - The Effect of Food Intake on the Pharmacokinetic of Single Dose SPH3127 Tablets in Chinese Health Subjects Phase 1
Completed NCT03100812 - Asian American Partnerships in Research and Empowerment (AsPIRE) N/A
Recruiting NCT03288142 - The Smart Hypertension Control Study N/A
Recruiting NCT03099343 - Tailored Messaging to Reduce Sodium Intake N/A
Completed NCT02147626 - Heart Health 4 Moms N/A
Not yet recruiting NCT03293147 - OUTREACH: Urine Analysis and Antihypertensive Treatment N/A
Recruiting NCT03264443 - Hypertension Approaches in the Elderly: a Lifestyle Study N/A
Not yet recruiting NCT02572765 - Evaluation of Splenic Metabolic Activity With 18FDG-PET in Hypertension N/A
Not yet recruiting NCT03267420 - Blood Pressure Measurement: Should Technique Define Targets? N/A
Not yet recruiting NCT03267329 - Duowell® vs. Telmisartan Monotherapy in Mild Dyslipidemia Patients With Hypertension Phase 4
Recruiting NCT02835287 - Diabetes Complication Control in Community Clinics (D4C) Trial N/A
Recruiting NCT02299414 - Chronic Hypertension and Pregnancy (CHAP) Project Phase 4
Recruiting NCT02909868 - CS-03 Pressure-Volume Loop Sub-study With RV Lead Positioning N/A
Recruiting NCT02919033 - Compare the Effects of Telemedicine Approach With Usual Care in Hypertension Management in China N/A