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NCT number NCT02913664
Study type Interventional
Source University of Texas Southwestern Medical Center
Contact Megha Sharma, BS
Phone 214-345-7134
Status Recruiting
Phase Phase 2/Phase 3
Start date September 2016
Completion date September 2022

Clinical Trial Summary

Physical inactivity, high blood pressure and dyslipidemia are risk factors for Alzheimer's disease (AD) and vascular dementia. Importantly, these risk factors are modifiable with lifestyle changes, pharmacological treatment, or both. The rrAD study will determine effects of aerobic exercise training and intensive vascular risk reduction on cognitive performance in older adults who have high risk for AD.

Clinical Trial Description

Numerous lines of evidence suggest that interventions that confer therapeutic benefit for cardiovascular health are also associated with improvements in, or preservation of, cognitive function. Many researchers and health care providers believe "What's good for the heart is good for the brain." However, stronger scientific evidence is needed to prove this hypothesis. The rrAD study is a 4-arm, multicenter, randomized trial to assess effects of aerobic exercise training and intensive pharmacological reduction of vascular risk factors on cognitive performance in older adults who have high risk for AD, that is, those who have high blood pressure, family history of dementia or subjective memory complaints. Furthermore, rrAD will examine effects of exercise and vascular risk reduction on brain volume, perfusion, and neural network connectivity using magnetic resonance imaging (MRI).

Study Design

Related Conditions & MeSH terms

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