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Hypertension clinical trials

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NCT ID: NCT03471533 Recruiting - Hypertension Clinical Trials

Efficacy of a Natural Ingredient on Blood Pressure

Start date: March 20, 2018
Phase: N/A
Study type: Interventional

Randomized controlled trial with two parallel branches (experimental product and placebo), double blind and unicentric with which it is intended to evaluate the efficacy of the product under investigation against placebo on blood pressure of normotensive subjects or with hypertension grade I without Pharmacotherapy. The subjects that meet the selection criteria will make a total of five visits to the research laboratory and perform the tests that were pre-established in the protocol. Later, a statistical analysis will be carried out with the variables measured in the study to obtain results.

NCT ID: NCT03470974 Enrolling by invitation - Clinical trials for Primary Hypertension

The Effect of Self-Titration and Predictors for Blood Pressure Control in Patients With Hypertension

Start date: February 3, 2017
Phase: N/A
Study type: Interventional

This study aims to investigate the relationship among self-efficacy, anxiety, depressive symptoms, quality of life, lifestyle, heart rate variability and blood pressure control; and to examine the effects of self-titration strategy on self-efficacy, anxiety, depressive symptoms,heart rate variability, sodium excretion, lifestyle modification,quality of life, and blood pressure control in patients with hypertension.

NCT ID: NCT03470701 Not yet recruiting - Hypertension Clinical Trials

Improving Albuminuria Screening Compliance Using a Smartphone Urinalysis Kit

Start date: April 2018
Phase: N/A
Study type: Interventional

This study will test the effectiveness of mailed, smartphone urinalysis kits to improve albuminuria screening compliance and detection of albuminuria.

NCT ID: NCT03470207 Not yet recruiting - Clinical trials for Chronic Thromboembolic Pulmonary Hypertension

The Prospective Risk Factor Evaluation & Discovery In CTEPH Study

Start date: March 2018
Phase: N/A
Study type: Interventional

This research study wants to find markers in the blood that may help to predict a patient's future risk of developing a disease called CTEPH. The study also wants to see if active monitoring for signs and symptoms of CTEPH after a pulmonary embolism (a blood clot in the lungs) can improve the diagnosis of CTEPH. Patients who enroll in this study will have periodic blood draws and clinic and/or phone follow-up to monitor for signs and symptoms of CTEPH. Patients' medical records will also be reviewed for information related to pulmonary embolisms and/or CTEPH.

NCT ID: NCT03468361 Enrolling by invitation - Hypertension Clinical Trials

Diuretic Effect Evaluation of Petroselinum Crispum (Parsley) in Hypertensive Patients

Start date: March 2018
Phase: N/A
Study type: Interventional

The use of alternative therapy, particularly herbal treatment is becoming prevalent among patients. Many herbs are in-use for various ailments such as diabetes, digestive problems, fever, hepatitis and hypertension etc. The common belief is, herbs are safe and easy to access as compared to conventional therapy, however, most of the studies reported different side effects which may be toxic at times. These adverse effects are mostly due to incorrect use or lack of patient education. Parsley is a plant with antioxidant, diuretic and antimicrobial properties. Literature reported use of parsley as a diuretic by different communities in throughout the world. In vitro studies in animal have also reported the diuretic effect as well as proposed mechanisms for the use of parsley as diuretic however none of the studies have been conducted to investigate the diuretic effect of parsley in humans. This study aims to evaluate the diuretic and hence antihypertensive effect of parsley in hypertensive patients.

NCT ID: NCT03465917 Recruiting - Hypertension Clinical Trials

Physiological Study of the Efficacy and Mechanistic Effects of Alcohol Renal Denervation

Start date: March 1, 2018
Phase: Early Phase 1
Study type: Interventional

Hypertension is a major risk factor for heart disease and stroke, two of the leading causes of death in the United States. Hypertension is a common and widespread problem; unfortunately, current treatment strategies fail to adequately control blood pressure in up to 50% of patients either because of failure to take prescribed medications (because of cost, side effects, inconvenience etc.) or lack of therapeutic response. Indeed, it is estimated that 50% of patients stop taking antihypertensive medication within 6-12 months after the initiation of drug therapy. Despite enthusiasm for a novel approach called renal denercation, presently there are no integrative studies of the antihypertensive effect of renal denervation on the multiple regulatory pathways it may consequentially affect. Experimental evidence from pre-clinical models suggests the effects are due to reducing efferent sympathetic activity and thus lowering blood pressure by altering the renin-angiotensin system. Uncontrolled clinical studies in humans suggest that when effective, this procedure may also lower renal sympathetic nerve activity. However the sympathetic response to monopolar radiofrequency therapy has been highly variable. Moreover, there have been no assessments of procedural efficacy performed in humans. Thus the actual mechanism by which this type of procedure reduces BP in humans is largely unknown, making it extremely difficult to identify the appropriate patients for this invasive procedure. Recently, chemical renal denervation using ethanol (EtOH), was demonstrated to markedly lower blood pressure in small numbers of patients with resistant hypertension. However the mechanisms by which blood pressure is altered using this novel technique in humans is entirely unknown, and procedural efficacy has also not been assessed. Therefore it is unclear, whether in humans renal sympathetic nerve activity is lowered following renal denervation using this new approach. The Investigators propose to use high resolution physiological testing to determine the effects of chemical renal artery denervation on sympathetic activity. Therefore the global objective of this physiological study is to provide the first detailed assessment of the integrated mechanistic effects of chemical renal nerve denervation in humans with hypertension that is uncontrolled by conventional treatment (because of lack of adherence or response to therapy).

NCT ID: NCT03465462 Completed - Hypertension Clinical Trials

The Influence of Hypotensive Drugs on Mineral Status in Experimental and Clinical Studies

Start date: January 2, 2016
Phase: N/A
Study type: Interventional

The aim of the study was to evaluate the effects of hypotensive treatment combined with a higher zinc supply in the diet and supplements on the mineral status and selected biochemical parameters of newly diagnosed hypertensive patients on monotherapy.

NCT ID: NCT03464864 Recruiting - Clinical trials for Pulmonary Arterial Hypertension

Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal Volunteers

Start date: March 9, 2018
Phase: Phase 1
Study type: Interventional

A Dose-Rising Clinical Trial to Evaluate the Pharmacokinetics, Safety and Tolerability of Treprostinil Inhalation Powder in Healthy Normal Volunteers

NCT ID: NCT03464591 Recruiting - Clinical trials for Pulmonary Hypertension

Cardiac Speckle Tracking Myocardial Strain Balance

Start date: November 1, 2017
Phase: N/A
Study type: Observational

The investigators intend to evaluate the function of left heart and right heart and the motion balance between four chambers of the heart by speckle tracking technique during the follow-up of patients with pulmonary hypertension, and explore the relationship between the balance and prognosis of patients.

NCT ID: NCT03463148 Enrolling by invitation - Hypertension Clinical Trials

Validation of a Sensor for Non-Invasive Measurements

Start date: October 24, 2017
Phase: N/A
Study type: Observational

Subjects will be measured with both a sensor and a reference device