Hypercholesterolemia Clinical Trial
Background: In recent years, probiotics have shown promise in treating a variety of
diseases. Previously, the investigators have reported on the clinical efficacy of bile salt
hydrolase active Lactobacillus reuteri NCIMB 30242 in improving the lipid profile in
hypercholesterolemic adults.
Objective: The purpose of the study is to investigate the effect of a delayed release or
standard vegetarian capsule containing L. reuteri NCIMB 30242, taken in escalated dose over
a 4 week period, on the plasma bile acid profile.
Design: The study design is a pilot, randomized, double-blind, dose-escalation study. The
study will last a total of 6 weeks, including a 4-week intervention period and a 2-week
washout period.
n/a
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator)
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