Clinical Trials Logo
  1. Home
  2. Human Microbiome
  3. NCT03942159

Modification of the Human Colon and Oral Microbiome by Allogenic HSCT

Human Microbiome Clinical Trial

Official title:
Modification of the Human Colon and Oral Microbiome by Allogeneic HSCT in Recipients and Correlation With the Microbiome of the Donor

Clinical Trial Summary

Allogenic HSCT brings significant changes in biodiversity and composition of the gut microbiome through antibiotic usage, the mucosal damage due to the chemo- and radiotherapy toxicity; compromised oral nutritional intake and graft-versus-host disease with gut damage as the complication. Aim of the study is to investigate the composition of the microbiota in both recipient and nursing relative donor, reveal changes in biodiversity after HSCT via 3-time points V3V4 16S rRNA and NGS sequencing of the colon and oral swabs, 3-indoxyl-sulfate measurement in the urine.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03942159
Study type Observational
Source Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Contact Zhanna Shekhovtsova
Phone 84956647078
Email zhanna.shekhovtsova@fccho-moscow.ru
Status Recruiting
Phase
Start date May 14, 2019
Completion date March 2023
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05560087 - Association of PeRiODontal Disease and gUt Microbiome With Coronary artEry Disease (PRODUCE Study)
Completed NCT04222699 - Cultures Before and After Decolonization in Community Dwelling Adults With Current S. Aureus Colonization Phase 4
Completed NCT02392182 - Lung HIV Microbiome Project (Michigan Site) N/A
Completed NCT04597502 - The Effects of Terminalia Chebula Fruit Extract on the Gut Microbiome and Skin Biophysical Properties N/A
Completed NCT04596722 - Oral Pomegranate Extract on the Microbiome and Skin Biophysical Properties N/A
Completed NCT02731976 - Microbiome Composition Changes on 4 Week Gluten-free Diet Challenge N/A
Completed NCT05150184 - Isolation and Characterization of Multiple Microbial Species From Diverse Healthy Adults
Completed NCT04335526 - A Clinical Study to Assess the Effect of Change of Bile Acid on the PD and Safety of Metformin and Microbiome Profiles Phase 1
Completed NCT03668015 - Xylitol and Sorbitol Effects on the Oral Microbiome N/A
Completed NCT03157687 - Detection of Luminal and Mucosa-associated Microbiome in Healthy Controls vs. Local and Systemic Inflammation
Not yet recruiting NCT04841694 - Oral Probiotics on the Shift in Gut Microbiome and Skin Carotenoid Levels N/A
Enrolling by invitation NCT03231332 - Effects of H.Pylori Eradication on Microbiome Phase 4
Completed NCT03181269 - Human Milk and Infant Intestinal Microbiome Study N/A
Completed NCT03543605 - Clinical/Microbiological Impact of a Specific Antimicrobial Stewardship Program for Nursing Homes N/A
Completed NCT01496898 - Changes in Vaginal, Cervical and Uterine Microflora With Levonorgestrel Intrauterine Device Placement N/A
Terminated NCT03907501 - Effects of Triphala and VSL#3 Probiotic Supplementation on Stool Microbiome Profiles and Inflammation N/A
Completed NCT03809260 - A Clinical Trial for Analysis of Intestinal Microbiome Affecting PK, PD, and Safety of Metformin N/A
Completed NCT04218799 - Human Microbiome and Healthcare Associated Infections - Nursing Home Dwelling Older Veterans Phase 4
Completed NCT03581812 - Snack Foods and Their Impact on Gastrointestinal Microbiology, Function and Symptoms N/A
Withdrawn NCT02407184 - Potential Restoration of the Infant Microbiome N/A