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Clinical Trial Summary

This is a randomised two-part Phase I study which will explore the impact of different boosting options (MVA-CN54 and recombinant CN54gp140 protein) for oral Adenovirus serotype 4 vector prime expressing HIV-1 CN54 envelope (Ad4-EnvCN54) designed to optimize systemic and mucosal antibody responses.

Part 1 is exploratory and designed to select conditions capable of promoting enhanced systemic and mucosal B cell responses in a limited number of participants. Part 2 is dependent upon Part 1 and is designed to study groups selected on performance in part 1 in an expanded number of subjects. Data from both stages will be combined for safety and immunological analyses.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03408262
Study type Interventional
Source Imperial College London
Contact Tom Cole, PhD
Phone 02033136198
Email t.cole@imperial.ac.uk
Status Recruiting
Phase Phase 1
Start date October 6, 2017
Completion date December 20, 2018

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