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HIV clinical trials

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NCT ID: NCT05483686 Completed - HIV Clinical Trials

Improving HIV Outcomes Among African American Transgender Women

Start date: November 16, 2021
Phase: N/A
Study type: Interventional

The investigators will conduct a randomized controlled trial to test the efficacy of the mobile HIV behavioral intervention for African American transgender women (Shine). Participants will be 215 trans women recruited by staff of the Trans Women of Color Collective via community events and social media. Participants must : 1) identify as a Black transgender woman using the 2-step method (Step 1: assigned male birth sex, Step 2: current gender identity is female); 2) be aged 18 or older; 3) report risk of HIV transmission in past 3 months (i.e., CAS with a serodiscordant or risky partner AND either <90% ART adherence or <5 daily doses of PrEP per week); 4) own a smartphone; and 5) be able to read and speak English. Eligible participants who subsequently provide informed consent will complete two confidential phone-based research surveys at different time points (baseline and 6 months post-baseline) and will be randomly assigned to one of two conditions (Shine or mobile HIV education for transgender women). Participants randomly assigned to the experimental condition will be instructed to text the word "Join" to the Shine study phone number. The intervention will take approximately 1-2 hours, with content delivered over several weeks. Participants randomly assigned to the control condition will be texted a link to a set of videos on healthy HIV-related behaviors for transgender women. These videos cover a variety of topics, including recommended testing frequencies, PrEP, and ART. After randomization, participants will complete the baseline research survey. This survey will assess the primary outcome of composite HIV transmission risk along with several secondary outcomes (individual behavioral components of the composite score; HIV medical care utilization and adherence; HIV testing; PrEP knowledge, interest, and uptake; gender affirmation; well-being; social support; sexual communication). Six months after the baseline research survey, all participants will complete a follow-up research survey assessing the same outcome measures in the baseline research survey. Binomial logistic regression will be the main analytic technique for the primary measure (composite risk for HIV transmission). For the secondary continuous measures, hierarchical linear modeling (HLM) will be used. All models will control for any demographic covariate (e.g., age) that varies at the .2 significance level due to randomization failure at baseline.

NCT ID: NCT05383456 Completed - HIV Clinical Trials

The Visceral Adiposity Measurement and Observation Study

VAMOS
Start date: April 18, 2022
Phase:
Study type: Observational

The Visceral Adiposity Measurement and Observation Study

NCT ID: NCT05282173 Completed - Depression Clinical Trials

Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa

Siyakhana
Start date: June 8, 2022
Phase: N/A
Study type: Interventional

Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up (LTFU) in HIV/TB care. Patients with depression and substance use (SU) have a greater likelihood of being LTFU in HIV/TB care, and there is evidence that CHWs may exhibit stigma towards these patients. When CHWs have negative attitudes towards these patients, on average they spend less time with these patients, are less likely to implement evidence-based practices, and deliver less patient-centered care. Therefore, this purpose of this study is to examine the implementation and preliminary effectiveness of a brief training ("Siyakhana"). The purpose of this training is to provide CHWs with psychoeducation, skills, and support around working with HIV/TB patients with depression/SU. The investigators will assess the training's implementation and changes in CHWs' stigma towards HIV/TB patients with depression/SU.

NCT ID: NCT05278572 Completed - Depression Clinical Trials

e-SMART/EST HIV Telehealth Intervention

eSMARTEST
Start date: January 25, 2023
Phase: N/A
Study type: Interventional

The goal of this project is to adapt an evidence-based, enhanced cognitive-behavioral stress management intervention (CSBM+) to target depression among older HIV-positive women in the Bronx, New York. The intervention, "Stress Management and Relaxation Training/Expressive Supportive Therapy" (SMART/EST), demonstrated effectiveness in numerous iterations over 15+ years, including trials with racially diverse HIV-positive women. To meet changing community needs including moving behavioral interventions to telehealth, we will pilot test e-SMART/EST, a teletherapy adaptation with peer support for HIV+ older women.

NCT ID: NCT05271903 Completed - Hiv Clinical Trials

Simulation Training for Labor and Delivery Providers to Address HIV Stigma During Childbirth in Tanzania

Start date: January 31, 2022
Phase: N/A
Study type: Interventional

This study will work in Tanzania to develop and pilot test a simulation and experiential learning intervention for labor and delivery providers, in order to address HIV stigma during childbirth. The primary endpoint will be patient-rated changes in respectful maternity care, comparing women who deliver in the pre-intervention time period and women who deliver in the post-intervention period.

NCT ID: NCT05270135 Completed - Hiv Clinical Trials

ASAP: Access to Syringes at Pharmacies for the Prevention of Bloodborne Infections Among People Who Inject Drugs

ASAP
Start date: December 1, 2022
Phase: N/A
Study type: Interventional

Access to Syringes at Pharmacies (ASAP) is a refinement of an evidence-based, pharmacy intervention to increase pharmacy-based sales of syringes to PWID in order to reduce bloodborne illnesses among them.

NCT ID: NCT05219552 Completed - Hiv Clinical Trials

Healthy Mothers: an Intervention to Support Perinatal Women Living With HIV in Kenya

Start date: February 23, 2022
Phase: N/A
Study type: Interventional

The investigators will recruit 40 pregnant women living with HIV divided into 2 groups (n=20 intervention group, n=20 control group). The intervention group will receive personalized lactation support and monthly unconditional cash transfers (100USD/month) from approximately 30 weeks pregnancy to approximately 6-months postpartum. The control group will receive the current standard care.

NCT ID: NCT05206123 Completed - Hiv Clinical Trials

Sexual Needs of Adolescents Living With HIV Since Childhood

SSVIH
Start date: March 17, 2022
Phase:
Study type: Observational

To improve the knowdelge about the sexual health needs of perinatally HIV-infected adolescents living in France.

NCT ID: NCT05195346 Completed - HIV Clinical Trials

Undetectable = Untransmissible in Thailand (888/64)

888/64
Start date: December 1, 2021
Phase:
Study type: Observational

This is a cross-sectional study to assess awareness, knowledge, and implementation of the concept of U=U among Thai PLHIV and Thai HIV healthcare providers, as well as associated factors. Data will be collected on an online survey platform called Alchemer. Questions on the survey will evaluate awareness, knowledge, and implementation of U=U among participants, as well as collect sociodemographic information of participants.

NCT ID: NCT05194059 Completed - Hiv Clinical Trials

'Activity Pacing' in PLWH With Fatigue Symptoms.

ActiPacMAN
Start date: December 3, 2021
Phase: N/A
Study type: Interventional

Physical activity helps to improve health and prevent chronic diseases. However, the fatigue usually hampers the training and execution of physical exercises, especially in people with chronic fatigue syndromes (CFCs), such as persons living with HIV (PLWH). We hypothesize that the "activity pacing", i.e. the strategy to optimize daily physical activity into manageable exercises in a way that should not exacerbate fatigue symptoms, may help a progressive improvement in physical activity of a group of PLWH with fatigue symptoms. Motivation and adherence to exercise will be monitored through the use of digital supports.