RA Effect on Cell Surface Molecules in Vivo

Status Withdrawn

Clinical Trial Summary

This study will follow a group of healthy male participants for about 18 weeks to see the effect of taking Acitretin on their immune cells

Clinical Trial Description

Retinoids have been shown in in vitro and ex vivo models to have the ability to reverse latency reactivating the HIV reservoir and the potential for selective eradication of HIV-harbouring cells. We feel that acitretin shows significant potential as a potential adjuvant to current ART regimens, however, there is a lack of data to demonstrate that treatment with acitretin at normal are able to induce molecular and transcription changes consistent with the above activities. In order to provide a scientific basis for retinoid therapy in HIV infection, a Phase I trial of acitretin in human subjects is proposed. ;

Study Design

Related Conditions & MeSH terms

HIV Infections

Clinical Trial Details

NCT number	NCT03753867
Study type	Interventional
Source	Ottawa Hospital Research Institute
Contact
Status	Withdrawn
Phase	Phase 1
Start date	January 7, 2019
Completion date	May 8, 2019

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