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HIV Infections clinical trials

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NCT ID: NCT03878147 Not yet recruiting - HIV Infections Clinical Trials

Neurodevelopmental Assessment of Children in Uganda and Malawi Using a Software Package

Start date: August 2019
Phase: N/A
Study type: Interventional

The investigators will use Brain Power Games, a computer-based learning game for children, as a neurocognitive "stress test" or medical "challenge" test, in order to evaluate brain/behavior functional integrity in HIV-affected children. This dual use of BPG is a key innovative feature. Each of the 5 core BPG games lasts 10 minutes and trains fine motor, monitoring/attention, visual/auditory working memory, spatial navigational learning. In Year 3 we'll add an Executive Functioning (EF) test to BPG. As an African child plays with BPG on a touch-screen tablet, BPG will use games as a dynamic window into the child's developing brain and EF-based frontal lobe development Aim 1. Evaluate concurrent and predictive validity of BPG static (baseline) and dynamic (during 12 training sessions) cognitive assessments Aim 2. Compare the validity of BPG static and dynamic assessments Aim 3. Test the sensitivity of dynamic assessment to learning loss over time by evaluating how much BPG performance gains diminish during a 6-month absence of training The investigator's central hypothesis is that the performance gains (dynamic assessment) will explain the additional variation in the gold-standard measures at time points after static (baseline) assessment, and more effectively capture the effects of HIV/ARV exposure and treatment across HIV affected cohorts (HIV, HEU, HUU) of children in Uganda and Malawi.

NCT ID: NCT03877536 Recruiting - HIV Infections Clinical Trials

Antiretroviral Therapy for Acute HIV Infection

Start date: March 17, 2019
Phase: N/A
Study type: Interventional

This study will evaluate the virologic effect, safety and tolerability of Genvoya® in adults during early acute HIV infection.

NCT ID: NCT03866759 Not yet recruiting - HIV Infections Clinical Trials

Prospective Observational Cohort HIV & STI Study in Europe

Start date: March 2019
Phase:
Study type: Observational

Investigators are sponsoring the Multicenter human immunodeficiency virus (HIV) and sexually transmitted infections Prevention Network Study (STIPnet) which is funded by Janssen, Pharmaceutical Companies of Johnson & Johnson. STIPnet study is a prospective observational cohort study aiming to determine the incidence and point prevalence of HIV infection and the most common sexually transmitted infections (STIs) in individuals with sexual risk behavior. In addition, investigators will examine whether individuals at risk for HIV and STI infections would retain in such a study (retention rate) and would be willing to participate in potential HIV and STI prevention trials (willingness to participate).

NCT ID: NCT03858998 Recruiting - HIV Infections Clinical Trials

Reducing Post-Hospital Mortality in HIV-infected Adults in Tanzania

Start date: March 5, 2019
Phase: Phase 3
Study type: Interventional

This research is being done to assess the efficacy of a case management intervention to improve the one year mortality rate of hospitalized, HIV-infected, Tanzanian adults.

NCT ID: NCT03856996 Not yet recruiting - HIV Infections Clinical Trials

A Clinical Trial in Healthy, HIV-1-Uninfected Adult Participants to Compare the Safety, Tolerability and Immunogenicity of CH505TF gp120 Produced From Stably Transfected Cells to CH505TF gp120 Produced From Transiently Transfected Cells

Start date: May 21, 2019
Phase: Phase 1
Study type: Interventional

The purpose of this study is to compare the safety, tolerability, and immunogenicity of CH505TF gp120 produced from stably transfected cells to CH505TF gp120 produced from transiently transfected cells in healthy, HIV-1-uninfected adult participants.

NCT ID: NCT03855176 Recruiting - Clinical trials for Human Immunodeficiency Virus

Effectiveness of Booster With 1 or 2 Doses of HAV Vaccine Among HIV-infected Patients

Start date: September 12, 2017
Phase: Phase 4
Study type: Interventional

Though HAV is mainly transmitted through the fecal-oral route, infection by sexual intercourse and blood transfusion is also possible. Injection drug users (IDUs) and men who have sex with men (MSM) have a higher risk of acquiring HAV due to their behaviors. Reemerging threat of hepatitis A among MSM in Taiwan has been reported recently. Based on the guidelines for the diagnosis and treatment of HIV/AIDS and the Advisory Committee on Immunization Practices (ACIP), Taiwan, vaccination of individuals against HAV with any of the following indications is recommended: HIV patients, adults with chronic hepatic disease, hemophilia, liver transplantation, occupational exposure, MSM, persons who use injection or noninjection illicit drugs, or persons traveling to or working in countries that have endemicity of HAV. In HIV-infected patients, the immunogenicity to HAV vaccination is sub-optimal in HIV-infected patients and the seroconversion rate is estimated 68-90% after administration of 2 or 3 doses of HAV vaccine. Furthermore, the antibody titers of HIV-infected patients following HAV vaccination are significantly lower compared to those of HIV-uninfected persons. The sub-optimal response among HIV-infected subjects remains an unresolved problem. In this study, the investigators aim to determine the to conduct a randomized clinical trial to compare the immunogenicity of 2 different doses of HAV vaccination (1 dose versus 2 doses) in HIV-infected patients who failed to achieve serologic response in the primary vaccination. This proposal will provide the solid evidence to elucidate the role of booster HAV vaccination in HIV-infected patients without response to primary HAV vaccination.

NCT ID: NCT03854630 Recruiting - HIV Infections Clinical Trials

Hepatitis B Virus Vaccination in HIV-positive Patients and Individuals at High Risk for HIV Infection

Start date: September 6, 2017
Phase: Phase 4
Study type: Interventional

The primary aim of this open-label, randomized control trial is to compare the immunogenicity at week 28 after 20µg HBV vaccine (at week 0, 4, 24) versus 40µg HBV vaccine (40-µg at week 0, 4, 24 week) among HIV-positive patients or HIV-negative MSM who were born in Taiwan after July 1986 and tested negative for all HBV serological markers. The secondary aims are to assess the safety of double-dose HBV vaccination, the proportions of high-level responders (anti-HBs antibody >100 mIU/ml) at weeks 28 and 48, the serological responses at week 48, and incident HBV infection (indicated by appearance of anti-HBc and/or HBsAg) at week 48.

NCT ID: NCT03853681 Not yet recruiting - HIV Infections Clinical Trials

Study on the Response to Tetanus Vaccination of People Living With HIV

VACTEVIH
Start date: March 11, 2019
Phase: N/A
Study type: Interventional

The response to primary tetanus immunization of HIV-infected children is lower than that of uninfected children. Response to tetanus toxoid (TT) booster doses in adults living with HIV who have received primary vaccination prior to infection is not known. Currently, it is recommended to have a TT booster for people living with HIV (PLHIV) every 10 years. In general population, this recall is made only at 25, 45 and 65 years, then every 10 years.

NCT ID: NCT03852849 Not yet recruiting - Clinical trials for Viral Suppression of HIV Infection

Rapid Build of HIV Related Protective Barriers

Start date: March 1, 2019
Phase: N/A
Study type: Interventional

The purpose of the study is to screen the optimal intervention strategies to rapid establish the protective barriers against HIV-infection by maximally decreasing the viremia among HIV- infected patients.

NCT ID: NCT03851588 Not yet recruiting - HIV Infections Clinical Trials

Standard Versus Double Dose Dolutegravir in Patients With HIV-associated Tuberculosis

RADIANT-TB
Start date: May 1, 2019
Phase: Phase 2
Study type: Interventional

The investigators propose to conduct a phase 2 randomised (1:1) double-blind placebo-controlled trial of the dolutegravir-lamivudine-tenofovir fixed dose combination tablet daily with an additional 50 mg dose of dolutegravir/matching placebo taken 12 hours later in ART-naïve HIV-infected patients on rifampicin-based anti-tuberculosis therapy. The hypothesis is that virologic outcomes with standard dose dolutegravir-based ART will be acceptable in patients on rifampicin-based anti-tuberculosis therapy.