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High Grade Dysplasia clinical trials

View clinical trials related to High Grade Dysplasia.

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NCT ID: NCT02396745 Terminated - Barrett Esophagus Clinical Trials

TECR & ECM Placement for Esophageal High Grade Dysplasia

Start date: January 25, 2016
Phase: N/A
Study type: Interventional

This study will test the safety and effectiveness of esophageal transoral endoscopic circumferential resection (TECR) using an extracellular matrix (ECM) placement to treat Barrett's esophagus in patients with high-grade dysplasia (HGD). Endoscopic circumferential resection using ECM placement has been introduced as a less invasive, externally incision-less approach to treat patients with esophageal high grade dysplasia; a pre-cancerous condition. In this procedure, the entire length of diseased (abnormal) mucosa (esophagus lining) will be removed using an endoscope that will be inserted through the mouth. The ECM will be placed over the area that is being removed with a temporary, expandable stent to prevent narrowing of the esophagus. The stent is being used to hold the ECM in place as the body begins the healing process. This stent will be removed 14 days (±4 days) after this procedure. Follow-up esophagogastroduodenoscopies (EGD), barium swallow x-ray tests, and questionnaires will take place for 12 months following the procedure. The result of this study may help doctors determine if this procedure would be a more effective treatment option for HGD in the future.

NCT ID: NCT01236443 Completed - Barrett's Esophagus Clinical Trials

Study of Photodynamic Therapy (PDT) Using HPPH in Barrett's Esophagus

Start date: August 2000
Phase: Phase 1
Study type: Interventional

A Study to identify toxicity and optimal photodynamic treatment parameters using the photosensitizer 2-[1-hydroxyethyl]-2-devinylpyropheophorbide-a (HPPH) in high grade dysplasia, carcinoma-in-situ, or early adenocarcinoma in Barrett's esophagus.

NCT ID: NCT00587600 Completed - Barrett's Esophagus Clinical Trials

Biomarkers in Phototherapy of Barrett's Esophagus

BIOBAR
Start date: December 2002
Phase: Phase 2/Phase 3
Study type: Interventional

This study is being done to find out if Photodynamic Therapy (treatment with a red light and a drug called photofrin) or Radiofrequency ablation works the same for patients who have biomarkers (abnormalities in molecules of cells that may or may not help predict cancer) present in their Barrett's esophagus as for patients who do not have biomarkers.

NCT ID: NCT00586989 Completed - Barretts Esophagus Clinical Trials

Endoscopic Tri-Modal Imaging in Patients With Barrett's Esophagus

ETMI
Start date: December 2007
Phase: N/A
Study type: Observational

This study is being done to determine if a new endoscope will help doctors identify pre-cancer or early cancer lesions in patients who have Barrett's esophagus. This new endoscope allows the doctor to look at the lining of the esophagus in 3 different ways by modifying light.

NCT ID: NCT00526786 Terminated - Barrett's Esophagus Clinical Trials

Study of CryoSpray Ablation of Low Grade or High Grade Dysplasia Within Barrett's Esophagus

ICE
Start date: September 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of the CryoSpray Ablation System to treat esophageal low grade dysplasia (LGD) or high grade dysplasia (HGD) within Barrett's Esophagus (BE).