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Clinical Trial Summary

Analysis of Gene expression and microbiome profiling in hidradenitis suppurativa to identify immunological biomarkers of disease activity.


Clinical Trial Description

A variety of molecular techniques can be used to investigate diseases by analyzing protein, DNA, and RNA. Flow cytometry, PCR, histology and immunohistochemistry are assays which can identify specific cell populations and provide valuable information regarding the pathologic characteristics of those populations. Flow cytometry analyzes the surface markers of cells. Histology and immunohistochemistry further characterize surface and cellular molecules and aid in the diagnosis of certain skin diseases. Gene expression profiling allows investigators to examine the genes detectable to determine the function of the cells involved, and PCR techniques are useful for the diagnosis of certain conditions and for DNA analysis.

By procuring blood, skin tissue, and swab samples from patients with and without neoplastic and inflammatory skin disorders at the time of their appointments, the hypothesize that future translational research can be conducted on such specimens using the aforementioned techniques to further understand disease mechanisms in cutaneous disorders, and to potentially discover defective function and genetic mutations within cells from patients with neoplastic and inflammatory skin disorders. By establishing a tissue bank, we aim to lay the foundation for future work that will improve our understanding of the biology and natural history of neoplastic and inflammatory cutaneous diseases. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03146676
Study type Observational
Source Ohio State University
Contact Rachel Moore
Phone 614-366-20025
Email rachel.moore3@osumc.edu
Status Recruiting
Phase N/A
Start date April 19, 2017
Completion date January 2022

See also
  Status Clinical Trial Phase
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Recruiting NCT03275870 - Hydroxychloroquine for the Treatment of Hidradenitis Suppurativa Phase 1/Phase 2
Active, not recruiting NCT03248531 - A Study to Test the Efficacy, Safety and Pharmacokinetics of Bimekizumab in Subjects With Moderate to Severe Hidradenitis Suppurativa. Phase 2
Completed NCT00329823 - Etanercept in Hidradenitis Suppurativa Phase 2
Terminated NCT03238469 - Microwave Ablation in Mild Axillary Hidradenitis Suppurativa N/A
Completed NCT01516749 - Anakinra as a Treatment for Hydradenitis Suppurativa Phase 2
Terminated NCT00722800 - A Study to Examine the Safety and Efficacy of Drospirenone and Ethinyl Estradiol (YAZ) Versus Placebo In HS Phase 2
Completed NCT00395187 - A Small Clinical Study: Photodynamic Therapy to Treat Hidradenitis Suppurativa N/A
Recruiting NCT03553888 - Hidradenitis Suppurativa and Periodontal Diseases
Completed NCT01838499 - Assessment of the Safety, Tolerability and Efficacy of MEDI8968 in Subjects With Moderate to Severe Hidradenitis Suppurativa Phase 2
Completed NCT01704534 - A Proof of Concept Study to Evaluate the Effectiveness of Ustekinumab in Hidradenitis Suppurativa Phase 2
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Enrolling by invitation NCT03572738 - Hidradenitis Suppurativa Mail Survey
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Completed NCT02833909 - Activation of a Cutaneous Inflammasome in the Skin of Hidradenitis Suppurativa Patients N/A
Recruiting NCT02163746 - Study to Compare Two Treatments for Axillary Hidradenitis Suppurativa: Carbon Dioxide Laser Versus Surgical Deroofing N/A
Recruiting NCT01818167 - An Investigation Into the Efficacy of Provodine Topical Cream as Compared to 10% Benzoyl Peroxide Wash for the Treatment of Hidradenitis Suppurativa. N/A
Completed NCT01558375 - Anakinra in Hidradenitis Suppurativa Phase 2
Completed NCT02593604 - Quality of Life After Wide Surgical Excision in Patients With Hidradenitis Suppurativa N/A
Recruiting NCT03040804 - Low Dose Radiotherapy for Advanced Hidradenitis Suppurativa N/A