Adjuvant Entecavir or Tenofovir for Postoperative HBV-HCC

Status Completed

Clinical Trial Summary

This study aims to compare the effect of antiviral therapy with entecavir or tenofovir for hepatitis B virus-related hepatocellular carcinoma after radical hepatectomy. Included patients will randomly divide into two groups.

Clinical Trial Description

Hepatocellular carcinoma (HCC) is associated with a poor prognosis, and its incidence has increased dramatically in many countries. Hepatectomy is a radical therapy for early-stage HCC. However, even after radical resection, the prognosis for HCC patients remains discouraging because of the high recurrence rate and frequent incidence of intrahepatic metastasis. Therefore, preventing HCC recurrence is very important. Hepatitis B virus (HBV) infection is the major risk factor for HCC development in China. Some retrospective studies have shown that tenofovir or entecavir treatment for HBV-related HCC patients can effectively reduce the HCC recurrence rate and increase the survival rate after hepatectomy. However, which drug has more efficacy has not been addressed. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT02650271
Study type	Interventional
Source	Guangxi Medical University
Contact
Status	Completed
Phase	Phase 3
Start date	February 2, 2021
Completion date	December 30, 2023

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