Hepatocellular Carcinoma Clinical Trial
Official title:
The Role of Quantitative Contrast-Enhanced Ultrasound in Yttrium-90 (90Y) Radioembolization of Hepatocellular Carcinoma
This pilot clinical trial studies how well contrast-enhanced ultrasound in diagnosing patients with liver cancer who are undergoing Yttrium-90 radioembolization. Contrast-enhanced ultrasound may provide detailed imaging of the tumor arteries after the injection of a contrast-agent consisting of microbubbles, and may predict how much Yttrium-90 will deposit in the tumor.
PRIMARY OBJECTIVES:
I. Investigate the relationship between hepatocellular carcinoma (HCC) tumor perfusion on
pre-procedural contrast-enhanced ultrasound (CEUS) time intensity curve (TIC) and
post-procedural Yttrium-90 (90Y) microsphere distribution after 90Y radioembolization (RE).
SECONDARY OBJECTIVES:
I. Study the potential of serial CEUS TIC examinations as a marker of tumor treatment
response as assessed at 20 - 24 week computed tomography (CT) follow-up.
OUTLINE:
Patients receive perflutren or sulfur hexafluoride lipid microspheres and undergo CEUS at
baseline, 2 and 4 weeks, and 3 and 6 months. Patients also undergo positron emission
tomography/computed tomography (PET/CT) after standard of care 90Y radioembolization at
baseline.
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