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Clinical Trial Summary

This is a phase I/II dose-escalation study of lipotecan based concurrent chemoradiotherapy in hepatocellular carcinoma with portal vein tumor thrombosis.


Clinical Trial Description

Protocol number: TLCTLC388A1008

Primary objective:

To evaluate the safety and tolerability, including maximum tolerated dose (MTD) and dose-limiting toxicity (DLT), of Lipotecan based concurrent chemoradiotherapy (CCRT) in patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombosis (PVTT) unsuitable for local treatment.

Secondary Objective:

The secondary objective is to explore the efficacy of Lipotecan based CCRT in patients with HCC and PVTT and the effect on quality of life. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03035006
Study type Interventional
Source Taiwan Liposome Company
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date April 14, 2017
Completion date October 31, 2018

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