Hepatocellular Carcinoma Clinical Trial
Official title:
The Efficacy and Safety of Retreatment With Transcatheter Arterial Infusion (TAI) for Patients Who Showed TACE-resistant: a Randomized Controlled Trial
Transarterial chemoembolization (TACE) is considered the gold standard for treating intermediate-stage hepatocellular carcinoma (HCC). However, any treatment guidelines do not specify the criteria for repeating TACE. The study,conducted in Europe ,recently published in the journal of Hepatology shows the ART score of >=2.5 prior the second TACE identifies patients with a dismal prognosis who may not profit from further TACE sessions. However,in clinical practice,we also found some patients who showed TACE-resistant at the beginning of treatment may access to get objective response of retreatment with transcatheter arterial infusion (TAI). So the investigators conduct this prospective,randomized controlled study to find out whether the patient who showed TACE-resistant can obtain survival benefit from retreatment with TAI.
Transarterial chemoembolization (TACE) is considered the gold standard for treating
intermediate-stage hepatocellular carcinoma (HCC). However, intermediate-stage HCC includes a
heterogeneous population of patients with varying tumour burdens, liver function (Child-Pugh
A or B) and disease aetiology.This suggests that not all patients with intermediate-stage HCC
will derive similar benefit from transcatheter arterial infusion (TAI), and that some
patients may benefit from other treatment options.
Repetition of TACE is based on evidence suggesting that one cycle of TACE may not be
sufficient for effective treatment of intermediate-stage HCC and repeating TACE prolongs
survival. However, intermediate-stage HCC patients often have unsatisfactory clinical
outcomes with repeated TACE and there is not sufficiently addressed by existing guidelines
include the criteria for repeating TACE and recommendations about the number of TACE cycles
to be repeated before switching to another or no treatment.The study,recently published in
the journal of Hepatology shows the ART score of >=2.5 prior the second TACE identifies
patients with a dismal prognosis who may not profit from further TACE sessions.In clinical
practice,however, we also found some patients who showed TACE-resistant at the beginning of
treatment may access to get objective response of retreatment with TAI. So we conduct this
prospective,randomized controlled study to find out whether the patient who showed
TACE-resistant can obtain survival benefit from retreatment with TAI.
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