Descending Aorta Blood Flow to Guide Fluid Therapy During Surgery

Hemodynamic Instability Clinical Trial

Official title:

Descending Aorta Blood Flow to Guide Fluid Therapy During Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05227729
• Other study ID #: 264472
• Status: Completed
• Start date: October 18, 2022
• Est. completion date: January 29, 2024

Study information

• Verified date: April 2024
• Source: Sykehuset Telemark
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The investigators will perform a clinical observational study of patients undergoing abdominal surgery. The study will be performed at Sykehuset Telemark, Skien. The aims of the study are to compare suprasternal and transoesophageal Doppler (reference method) to measure blood flow in the proximal descending aorta and to explore the variability of hemodynamic variables during surgery.

Description:

Background and aim: The best validated method to estimate cardiac output with ultrasound requires measuring the Doppler velocity time integral (VTI) in the left ventricular outflow tract measured from the apical (lateral chest) window/ projection. However, this projection is often out of reach for anaesthesiologists during many surgical procedures (e.g. abdominal surgery) due to draping, and is often difficult to perform if the patient cannot be placed in the left lateral decubitus position. Alternatively, VTI in the proximal descending aorta may be measured via the suprasternal view, which is one of the standard projections in transthoracic echocardiography. This view is often available for anaesthesiologists during surgery on a patient in supine position. Assuming that changes in cardiac output are associated with changes in VTI in proximal descending aorta, this may provide the anaesthesiologist with a non-invasive measure of the response to a fluid challenge. The first aim of this study is to evaluate the ability of suprasternal Doppler to measure blood flow in the proximal descending aorta, and its agreement with the reference method oesophageal Doppler, during ongoing abdominal surgery.

Fluid challenges are typically given when stroke volume is reduced by 10-15%, which is considered a significant reduction. This is however dependent on the precision of the measurements, which is estimated during hemodynamic stability. During surgery, on the other hand, the variability may be larger, leading to erroneously concluding that stroke volume is reduced due to volume loss, when in fact this may be due to other stimuli related to surgery (mechanical, e.g. compression of large veins or the thoracic cavity, or stimuli affecting the autonomic nervous system, e.g. pain). The proportion of potentially falsely measured reduction may be calculated by performing repeated measurements during ongoing surgery. Thus, an other aim with this study is to explore the variability of measurements of stroke volume during surgery.

Study design: Clinical observational study.

Data collection: 30 patients scheduled to undergo laparoscopic or open abdominal surgical procedures (gastrointestinal or gynecological) of at least 1.5 hrs estimated duration. The patients should be of American Society of Anesthesiologists physical status 1-3 and have no contraindications to the use of oesophageal ultrasound. Hemodynamic data will be downloaded to a PC continuously from the clinical monitoring equipment (Philips Intellivue) using the VSCapture software (https://github.com/xeonfusion/VSCaptureMP) in VisualStudio (Microsoft). "Landmarks" in the procedure (e.g. surgical incision, manipulation in the surgical field and hemorrhage) will be recorded manually to relate the hemodynamic data to the different steps in the procedure. Blood flow velocity in the descending aorta will be measured using ultrasound machines in ordinary clinical use (GE Venue R 2.5; GE Healthcare). The Doppler recordings will be analyzed using commercially available software (EchoPAC; General Electric) after blinding.

Data analyzes:

• Considerations regarding sample size for agreement analyzes: The investigators will focus on within-subject variability, and the main outcome will be the corresponding within-subject limits of agreement. If both methods have a precision of 2.9%, limits of agreement will be 8.3%. Given 18 measurements per subject (one measurement every 5 min over 1.5 hrs), 25 subjects will give an 80% power for an upper confidence interval of the limits of agreement of 18%. By including 30 patients, the investigators allow for some unsuccessful measurements due to e.g. poor echogenicity.

• Considerations regarding sample size for variability analyzes: Given that the SD of oesophageal Doppler is 2.9%, the precision is 2.9%×1.96=5.7%. The probability of each evaluation of showing a false reduction is 0.8%. If surgery lasts 1.5 hrs with one evaluation every 5 min, the probability of at least one false reduction is 12%. If the precision is reduced with a doubled SD, the probability of at least one false reduction is 88%. Assuming a true SD of 2.9%; studying 25 subjects gives a power of 0.8 to detect a SD <3.0%.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: January 29, 2024
• Est. primary completion date: January 29, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients scheduled to undergo laparoscopic or open abdominal surgical procedures (gastrointestinal or gynecological) of at least 1.5 h estimated duration.

• The patients should be of American Society of Anesthesiologists physical status 1-3

Exclusion Criteria:

• Pathology in the larynx, oesophagus or stomach

• Former surgery in larynx, oesophagus or stomach

• Thoracic aortic aneurysm.

Related Conditions & MeSH terms

• Hemodynamic Instability

Intervention

Diagnostic Test:
• Measurement of blood flow in descending aorta by suprasternal ultrasound Doppler technique
While study subjects are in general anesthesia the investigator will perform repeated measurements every 5 min.
• Measurement of blood flow in descending aorta by transoesophageal ultrasound Doppler technique
While study subjects are in general anesthesia the investigator will perform repeated measurements every 5 min.

Locations

Country	Name	City	State
Norway	Telemark Hospital Trust	Skien	Vestfold Og Telemark

Sponsors (3)

Lead Sponsor	Collaborator
Sykehuset Telemark	Oslo University Hospital, University of Oslo

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in blood flow velocity in descending aorta	Suprasternal Doppler	During surgery, every 5 minutes. At least over a time period of 1,5 hours
Primary	Change in blood flow velocity in descending aorta	Transoesophageal Doppler	During surgery, every 5 minutes. At least over a time period of 1,5 hours
Primary	Change in stroke volume	Calculated from the measurements by transoesophageal Doppler	During surgery, every 5 minutes. At least over a time period of 1,5 hours
Secondary	Change in heart rate	Measured in beats per minute, collected from standard monitoring device during surgery	During surgery, every 5 minutes. At least over a time period of 1,5 hours
Secondary	Change in systemic vascular resistance	Measured in dynes/second/cm^5. Calculated from the measurements by transoesophageal Doppler and standard monitoring device (mean arterial pressure)	During surgery, every 5 minutes. At least over a time period of 1,5 hours
Secondary	Change in blood pressure	Measured in mmHg, collected from standard monitoring device during surgery	During surgery, every 5 minutes. At least over a time period of 1,5 hours