Graft Vs Host Disease Clinical Trial
Official title:
Characteristics and Dynamics of TCR Repertoire in Peripheral Blood of Patients With Hematological Malignancies After Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation
Graft-versus-Host Disease (GVHD) and relapse, which is mainly due to lack of
Graft-versus-Leukemia (GVL), are the most frequent and severe complications of allogeneic
hematopoietic stem cell transplantation (allo-HSCT). T cells expanded from mature T cells in
the graft play a dominant role in development of GVHD and GVL early after allo-HSCT. Recent
applications of high-throughput sequencing (HTS) to the T cells repertoire open a new avenue
for us to look deeply into how these T cells dynamically adjust in the context of the
recipient's environment.
The main goal of this research study is to set up a mathematical model based on T cell
receptor (TCR) sequencing to enable prediction for the key immunologic outcomes early
post-transplantation. This study will deepen the understanding of the molecular mechanisms
driving the most deadly post-transplantation complications, and serve as convincing evidence
upon which to choose a better donor and a more proper transplantation approach.
This observational trial will perform HTS for TCR β-chain complementarity determining region
3 (CDR3) repertoires of grafts and peripheral blood samples from recipients
post-transplantation and analyze the relationship between dynamics of TCR CDR3 repertoires
and clinical outcomes early post-transplantation, especially including GVHD and relapse. The
investigators want to know how the antigen environment in recipients drives dynamics of
mature T cells from grafts in order to use the new discovered rules to better predict and
treat the disease process.
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