Heart Failure Clinical Trial
Official title:
Effects of Aerobic Exercise on Telomere Length in Patients With Systolic Heart Failure: A Randomized Clinical Trial.
The present study will analyze and compare the chronic effects of aerobic exercise in subjects with systolic heart failure on telomere length.
Status | Not yet recruiting |
Enrollment | 24 |
Est. completion date | December 30, 2021 |
Est. primary completion date | August 30, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 50 Years to 80 Years |
Eligibility | Inclusion Criteria: - Primary diagnosis of HF with ejection fraction <40%; - Clinically stable patients with at least three months on optimal HF treatment; - Age between 50 and 80 years; - New York Heart Association (NYHA) functional class II to III; - No contraindications to participate in an exercise program; - Mentally able to understand instructions during the study. Exclusion Criteria: - Severe valve disease; - Peripheral artery disease with symptoms of intermittent claudication; - Uncontrolled hypertension; - Drug or alcohol abuse; - Cognitive and/or osteomyoarticular conditions that prevent exercise; - Logistical impossibility of attending the hospital intervention; - Engaging in supervised physical exercise in the past three months; - Do not complete the run-in period. |
Country | Name | City | State |
---|---|---|---|
Brazil | Hospital de Clínicas de Porto Alegre | Porto Alegre | RS |
Lead Sponsor | Collaborator |
---|---|
Hospital de Clinicas de Porto Alegre |
Brazil,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Biological Aging | Telomere Length | 16 weeks | |
Secondary | Aerobic Capacity | Cardiopulmonary Exercise Test - VO2peak | 16 weeks | |
Secondary | Echocardiography Variables | Differents echocardiography variables such as Strain Global Longitudinal | 16 weeks | |
Secondary | Endothelial Function | Flow-mediated dilation (FMD) of Brachial Artery | 16 weeks | |
Secondary | SSWS | Walking Ability measured by a Self-Selected Walking Speed Test (SSWST) | 16 weeks |
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