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Clinical Trial Summary

Heart failure has a high morbidity and mortality because the heart is one of the least regenerative organs in a human body. Drug treatments for heart failure manage symptoms but do not restore lost myocytes. Cellular replacement therapy is a potential approach to repair damaged myocardial tissue, restore cardiac function, which has become a new strategy for the treatment of heart failure. The purpose of this study is to assess the safety, feasibility and efficacy of intramyocardial delivery of regenerated cardiomyocytes at the time of coronary artery bypass grafting in patients with chronic ischemic cardiomyopathy.


Clinical Trial Description

Patients with heart failure will be treated with allogenic human induced pluripotent stem cell-derived cardiomyocytes ( hPSC-CM ) from healthy donors. The cells will be injected directly into the myocardium at time of coronary artery bypass grafting. Patients will be followed for 12 months for safety, feasibility and efficacy assessment of therapy. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03763136
Study type Interventional
Source Help Therapeutics
Contact Jiaxian Wang, Phd
Phone +86-18565616060
Email wangjx@helpsci.com.cn
Status Recruiting
Phase N/A
Start date December 1, 2018
Completion date December 1, 2020

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