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Clinical Trial Summary

The researchers want to find out more about the effect of a single dose of oral myeloperoxidase on heart failure versus placebo.


Clinical Trial Description

Enroll subjects with a normal ejection fraction referred to the catheterization laboratory for evaluation of breathlessness or shortness of breath. During the catheterization researchers will perform blood draws, assessment of endothelial function, assess baseline exercise capacity at rest and during exercise. During the catheterization procedure researchers will do an echocardiogram to take measurements of the heart. Subjects will be randomized to one of two groups, Oral Myeloperoxidase Inhibitor or placebo group. Study drug or placebo will be administered followed by a repeat of resting and exercise testing. During that time blood measurements are taken. At the conclusion of the second exercise test the subject will be moved to a room and monitored overnight for safety. Repeat blood draws, echocardiogram, endothelial function test, and heart monitoring will be completed. The subject will be asked to follow up with the researchers between 9-14 days after the study drug dosage. The subjects history and blood work will be completed at that visit. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03611153
Study type Interventional
Source Mayo Clinic
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date July 1, 2018
Completion date December 31, 2020

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