Clinical Trials Logo
NCT number NCT03187509
Study type Interventional
Source New York City Health and Hospitals Corporation
Contact Robert Siegel, MD
Phone 718-918-5900
Status Not yet recruiting
Phase N/A
Start date July 2017
Completion date September 2018

Clinical Trial Summary

This study will be a randomized open-label pilot study. The purpose of the study is to compare standard of care outpatient heart failure management versus a weight based torsemide regimen. Subjects admitted to the hospital for heart failure exacerbation will be randomized upon discharge to either standard of care outpatient heart failure management or a weight based torsemide regimen. Those subjects randomized to standard of care therapy will be prescribed a daily fixed dose of a loop diuretic at hospital discharge and have a follow-up appointment within one week of discharge. All management decisions including loop diuretic type, dose and frequency will be made at the discretion of the subject's personal physician. Those randomized to an individualized weight based torsemide regimen will be prescribed a dose of torsemide upon hospital discharge based on a prespecified algorithm. These subjects will then undergo physician-subject phone encounters three times a week where the subject's torsemide dose will be modified based on the prespecified algorithm which incorporates current symptoms and weight. Primary end-point will be an unbiased estimate of 30-day all cause readmission rates. Secondary end-points include incidence of acute kidney injury, changes in brain natriuretic peptide levels from baseline and a preliminary estimate of the effect size and feasibility of a weight-based torsemide regimen intervention in order to plan a future larger study.

Clinical Trial Description


Study Design

Related Conditions & MeSH terms

See also
Status Clinical Trial Phase
 Not yet recruiting NCT03170466 - Primary Palliative Care in Heart Failure: A Pilot Trial N/A
 Not yet recruiting NCT03003780 - Mindful Steps: Promoting Physical Activity N/A
 Not yet recruiting NCT02922036 - Stimulation Of the Left Ventricular Endocardium for Cardiac Resynchronization Therapy in Non-Responders and Previously Untreatable Patients Phase 3
 Not yet recruiting NCT02784912 - Biomarkers in Risk Stratification of Sustainted Ventricular Tachycardia or Electrical Storm After Ablation N/A
 Recruiting NCT02713126 - Inorganic Nitrite to Amplify the Benefits and Tolerability of Exercise Training in HFpEF (INABLE-Training) Phase 2
 Recruiting NCT02921607 - Development of Scalable New Model(s) Focused on Care Co-ordination and Care Provision for Medically Complex, Co-morbid Chronic Disease Patient Segments Focusing on Heart Failure N/A
 Recruiting NCT02911493 - Reducing Sedentary Time in Patients With Heart Failure N/A
 Recruiting NCT02864420 - Hospitalization at Home: The Acute Care Home Hospital Program for Adults N/A
 Recruiting NCT03013270 - Aerobic, Resistance, Inspiratory Training Outcomes in Heart Failure N/A
 Recruiting NCT02823795 - The Supporting Patient Activation in Transition to Home Intervention N/A
 Recruiting NCT03071952 - Assessment of AAIR Pacing Treatment for Heart Failure Patients With Chronotropic Incompetence N/A
 Recruiting NCT02914665 - A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart Failure Phase 2
 Active, not recruiting NCT02922478 - Role of Comorbidities in Chronic Heart Failure Study N/A
 Not yet recruiting NCT02877914 - China PEACE 5r-HF Study N/A
 Not yet recruiting NCT02821065 - Telehealth for Emergency-Community Continuity of Care Connectivity Via Home-Telemonitoring N/A
 Withdrawn NCT02624960 - Safety and Performance of the AccuCinch® System N/A
 Not yet recruiting NCT02903940 - The Application of Negative Atrioventricular Hysteresis in Cardiac Resynchronization Therapy N/A
 Not yet recruiting NCT02899364 - Sodium Thiosulfate to Preserve Cardiac Function in STEMI Phase 2
 Recruiting NCT02525185 - Contractile Reserve in Dyssynchrony: A Novel Principle to Identify Candidates for Cardiac Resynchronization Therapy N/A
 Recruiting NCT02598505 - Indacaterol in Heart Failure Patients: Any Role on Lung Fluid Regulation Phase 3