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Clinical Trial Summary

The aim of the present study is the evaluation of the occurrence and effect of hepatic dysfunction on outcome following cardiac surgery, as well as the monitoring of changes in liver haemodynamics in the early postoperative period.


Clinical Trial Description

Prospective, consecutive study of patients undergoing cardiac surgery in Heart and Vascular Center, Semmelweis University, Budapest.

Registered data:

- Anamnestic and demographic data

- Liver dysfunction prior surgery, etiology of liver dysfunction

- Perioperative clinical data: laboratory tests, imaging, haemodynamic measures

- risk prediction score of the American Society of Anesthesiologists(ASA), EUROpean System for Cardiac Operative Risk Evaluation (EuroScore), Acute Physiology and Chronic Health Evaluation II (APACHE II), Simplified Acute Physiology Score (SAPS II), Canadian Cardiovascular Society grading of angina pectoris (CCS)

- Model for End-Stage Liver Disease (MELD), MELD excluding International Normalised Ratio (INR) (MELD-XI), modified MELD score (modMELD), Child-Pugh

The occurrence and etiology pattern of hepatic impairment are going to be evaluated according to age and type of cardiac illness. Correlations between perioperative haemodynamical alterations and structural, functional changes in hepatic status will be investigated.

The impact of hepatic impairment on surgical outcome is going to be examined by multivariate regression models. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02893657
Study type Observational [Patient Registry]
Source Semmelweis University Heart and Vascular Center
Contact Andrea Székely, MD, PhD
Phone +36206632243
Email andi_szekely@yahoo.com
Status Recruiting
Phase
Start date December 1, 2017
Completion date September 2019

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