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Clinical Trial Summary

The study tested the usefulness of cardiopulmonary exercise test (CPET) in selection of potential responders to CRT.


Clinical Trial Description

Cardiac resynchronization therapy (CRT) is an acknowledged therapy of selected patients with heart failure (HF). One of the unresolved problems is high percentage of non-responders to CRT, reaching 40%. No single parameter, helpful in identifying non-responders prior to CRT implantation, was found.

The study included patients with HF of ischemic or non-ischemic etiology, in NYHA class II-IV, EF≤35% and QRS≥120ms. All the patients had CRT implanted. Clinical evaluation, CPET and NT-proBNP levels measurement were performed before CRT implantation and after 3-6 months. Improvement in HF symptoms of one or more NYHA class correlated with two-years survival. It was used as the criterion of positive response to CRT. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03870074
Study type Observational
Source Institute of Cardiology, Warsaw, Poland
Contact
Status Completed
Phase
Start date October 2009
Completion date October 2017

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