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Clinical Trial Summary

The aim of the work is to Evaluate the efficacy, quality of life and safety of early addition of ivabradine to B-blocker in reduced EF heart failure patients after acute decompensation compared to the standard treatment.


Clinical Trial Description

this study is a Prospective randomized open label study will be conducted on Egyptian patient with heart failure with reduced ejection fraction(rEF HF). Each of the eligible patients will be randomized to one of these groups, early administration of Ivabradine and B-blocker group or control group which follows American Heart Association treatment guidelines of rEF HF.

The objectives include the following:

1. Physical examination (heart rate, blood pressure, dyspnea and orthopnea symptoms)

2. NYHA class

3. Pro-NT-BNP serum level, ST2 serum level

4. Echocardiography (left ventricular ejection fraction)

5. Score of Minnesota Living with Heart Failure Questionnaire these objectives will be measured baseline, 2 weeks and after 3 months ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03701880
Study type Interventional
Source Ain Shams University
Contact
Status Active, not recruiting
Phase N/A
Start date September 16, 2018
Completion date December 23, 2019

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