Heart Failure With Reduced Ejection Fraction Clinical Trial
Official title:
Bisoprolol Plasma Residual Concentrations for the Optimization of Drug Management in Heart Failure With Mild to Reduced Ejection Fraction
This study evaluate the dosage of bisoprolol plasma residual concentrations in chronic heart failure with mild to reduced ejection fraction adult patients by dose and renal function.
The clinical relevance of bisoprolol plasma residual concentration in the management of HF
medical therapy and the impact of renal function on reaching the maximum tolerated dose has
never been studied. The investigators will perform an observational study to answer this
issue.
In this study, there will be no changes of the doses of bisoprolol, whatever the bisoprolol
plasma concentration, with the exception of vital threatening concentrations. This study is a
pilot study.
Participants will be consecutive ambulatory chronic heart failure patients followed at the
CHU de Caen, treated with maximum tolerated dose of bisoprolol with mild to reduced ejection
fraction. Participants can benefit of the other heart failure recommended treatment at the
exception of ivabradine that would confound the bisoprolol effect on heart rate. Participants
will be subsequently studied by renal function.
Patients will be followed at one year with the electronic health record of the CHU de Caen
for clinical events.
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