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Clinical Trial Summary

Beta blockers have been used to reduce the mortality and heart failure rehospitalization in heart failure with reduced ejection fraction (HFrEF) patients in addition to ACEI/ARB, MRA, ivabradine and ARNI. However, the effective and safe medical therapy is not well established in heart failure with preserved ejection fraction (HFpEF) yet. Recent meta-analysis showed that beta blockers may also be beneficial for reducing the mortality and heart failure rehospitalization in HFpEF like HFrEF. However, the clinical effect and safety of carvedilol have been largely unknown in HFpEF. Therefore, CAYMUS HFpEF is the exploratory study to assess the change of surrogate markers (NTproBNP, hsTn) when treated with carvedilol SR vs. placebo in HFpEF patients


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03948685
Study type Interventional
Source Yonsei University
Contact Seok-Min Kang, MD, Ph.D
Phone 82-2-2228-8450
Email smkang@yuhs.ac
Status Not yet recruiting
Phase Phase 4
Start date May 2019
Completion date January 2021

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