Heart Failure, Congestive Clinical Trial
Official title:
Evaluation of Enalapril Versus Placebo in Patients With Diastolic Heart Failure
BACKGROUND: Exercise intolerance is the primary symptom in older patients with heart failure
and preserved ejection fraction (HFPEF), however little is known regarding its mechanisms and
therapy.
METHODS: 71 elderly stable, compensated HFPEF patients (age 70+1 years; 80% women) with
controlled blood pressure were randomized into a 12 month follow-up (FU) double-blind trial
of enalapril 20 mg per day (E) vs. placebo (P). Assessments included: peak exercise oxygen
consumption (VO2); six-minute walk test; Minnesota Living with HF Questionnaire (MLHF); MRI;
Doppler-echocardiography; and vascular ultrasound.
n/a
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