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NCT00600652 Clinical Trial

FCM Analysis GR in Steroid-Treatment Patients

Healthy Clinical Trial

Official title:
Flow Cytometric Analysis of Glucocorticoid Receptor Using Monoclonal Antibody and Fluoresceinated Ligand Probes in Glucocorticoid-Resistant and -Sensitive Patients

Clinical Trial Details — Status: Enrolling by invitation

Administrative data
NCT number NCT00600652
Other study ID # 061210
Secondary ID 30730114
Status Enrolling by invitation
Phase N/A
First received January 15, 2008
Last updated January 24, 2008
Start date December 2006

Study information
Verified date January 2008
Source Changhai Hospital
Contact n/a
Is FDA regulated No
Health authority China: Ethics Committee
Study type Observational

Clinical Trial Summary

Monitoring the GR with a GR-MoAb and FITC-Dex probes by FCM would be useful and convenient in determination GR before the steroid treatment in clinical, especially in steroid resistant states, in order to design more efficient clinical treatment protocols.

Description:

In order to assess the efficacy of this method, 100 patients with nephrotic syndrome and systemic lupus erythematosus receiving sufficient prednisolone thereafter and 50 age- and sex-matched normal controls will be studied.

Recruitment information / eligibility
Status Enrolling by invitation
Enrollment 150
Est. completion date
Est. primary completion date December 2010
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 15 Years to 65 Years
Eligibility Inclusion Criteria:

- Clinical diagnosis of SLE and NS

Exclusion Criteria:

- Receiving hormone replacement therapy or had received hormone replacement therapy in three months before start of the study

- Received drugs or drinks containing alcohol within one month

- Having symptom such as infection

- Supersensitivity and endocrine disturbance.

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Changhai Hospital
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