Plant-based Dietary Protein and Resistance-training Adaptations

Healthy Clinical Trial

Official title:

Does Exclusive Consumption of Plant-based Dietary Protein Impair Resistance Training-induced Muscle Adaptations?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03907059
• Other study ID #: 54014116.9.0000.5391
• Status: Completed
• Phase: N/A
• Start date: March 31, 2017
• Est. completion date: October 19, 2018

Study information

• Verified date: April 2019
• Source: University of Sao Paulo
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dietary protein consumption maximizes the anabolic response during resistance training (RT) by triggering muscle protein synthesis and providing the indispensable amino acids for a net positive protein balance. Leucine is considered the key amino acid in this process, suggesting that differences in protein quality may influence RT-induced gains in muscle mass and strength. In general, plant-based protein sources have lower leucine concentrations than animal-based protein sources and human skeletal muscle. In this respect, despite acute evidence on lower anabolic properties of plant- vs. animal-based protein, the effects of an exclusive plant-based dietary protein diet on RT-induced adaptations are currently unknown.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 38
• Est. completion date: October 19, 2018
• Est. primary completion date: October 16, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy young men

• Vegans = 1 y or omnivorous subjects

• Physically active but no resistance-trained subjects

• Without any chronic injury that impairs resistance training performance

• Protein intake > 0.8 g/protein/kg body weight

Exclusion Criteria:

• Use of creatine or beta-alanine supplements for the last 3 months

• Use of proteins and/or amino acids supplements for the last 1 month

• Engagement in specific dietary restrictions

• Previous use of anabolic steroids

• Engagement in any training program

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• whey protein
supplementation individually adjusted to 1.6g/kg/day
• soy protein
supplementation individually adjusted to 1.6g/kg/day

Locations

Country	Name	City	State
Brazil	University of Sao Paulo	Sao Paulo	SP

Sponsors (1)

Lead Sponsor	Collaborator
University of Sao Paulo

Country where clinical trial is conducted

Brazil, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle cross-sectional area	assessed by mode-B ultrasound	12 weeks
Primary	Muscle strength	assessed by leg-press one-maximum-repetition	12 weeks
Secondary	Leg lean mass	assessed by Dual-energy X-ray absorptiometry	12 weeks
Secondary	fiber cross-sectional area	assessed by muscle biopsy (vastus lateralis)	12 weeks