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Clinical Trial Summary

The primary objective of this study is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET radiopharmaceutical [18F]DPA-714 in individuals with chronic pain and fatigue suspected to be associated with neuroinflammation. The PET tracer [18F]DPA-714 binds to the 18 kDa translocator protein (TSPO, also known as the peripheral benzodiazepine receptor) in the mitochondria of activated microglia/macrophages and provides a non-invasive measure of neuroinflammation. The primary objective of this study is to determine if pain and fatigue patients have higher levels of neuroinflammation than HC individuals as measured with [18F]DPA-714-PET/MRI.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT03759522
Study type Interventional
Source University of Alabama at Birmingham
Contact Jonathan McConathy, MD, PhD
Phone 205-996-7115
Email jmconathy@uabmc.edu
Status Not yet recruiting
Phase Phase 1
Start date February 1, 2019
Completion date November 1, 2021

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