Healthy Clinical Trial
Official title:
Effect of Metformin and Probiotics on Gut Microbiome in Healthy Subjects: a Randomized, Double-blind Study.
This clinical trial is designed to evaluate the alteration of gut microbiome in healthy subjects after a 12-week metformin and/or probiotics administration.
Gut microbiome dysbiosis have been linked with the onset and progression of several diseases.
Metformin and probiotics have been confirmed to function partly by regulating the gut
microbiome. The investigators are now wondering if metformin/probiotics treatment will change
the gut microbiota in healthy subjects and show some benefits.
In this study, about 60 healthy subjects will be enrolled. Participants will be randomly
assigned into one of the following three groups: Metformin powder (0.5g tid po), Probiotics
powder (0.5g tid po), Placebo powder (0.5g tid po), for 12 weeks.
Blood and stool samples will be collected before and after treatment. Fasting glucose levels,
fasting insulin levels, serum lipid profiles, inflammation markers and alteration of gut
microbiota will be evaluated.
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