Healthy Clinical Trial
Official title:
The Interaction Between Oxytocin and Serotonin on the Social-reward Brain Networks and Decision Making
The primary objective of this study is to identify any interaction between oxytocin and serotonin on neural and behavioral activity related to social reward and decision making by a double-blind, placebo-controlled, between-subject, pharmacological fMRI design
Status | Recruiting |
Enrollment | 100 |
Est. completion date | July 20, 2019 |
Est. primary completion date | June 20, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 30 Years |
Eligibility |
Inclusion Criteria: - Healthy subjects without past or current psychiatric or neurological disorders - Right-handedness Exclusion Criteria: - History of head injury; - Medical or psychiatric illness. - High blood pressure, general cardio-vascular alterations - History of drug or alcohol abuse or addiction. - Allergy against medications or general strong allergies - Sleep disorders. - Visual or motor impairments |
Country | Name | City | State |
---|---|---|---|
China | Beijing Normal University | Beijing |
Lead Sponsor | Collaborator |
---|---|
University of Electronic Science and Technology of China |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Changes in brain neural activity during the social reward processing as assessed via fMRI | Whole brain and region of interest (ROI) regression analysis will be used to compare the neural activity of participants in response to social reward task in different treatment groups. | approximately 45 minutes after intranasal administration of oxytocin, or placebo, approximately 5.5h after administration of ATD, or placebo | |
Primary | Changes in the resting state as assessed via fMRI | Resting state activity in the social reward related and decision making brain networks will be compared between the treatment groups | Time Frame: approximately 45 minutes after intranasal administration of oxytocin, or placebo, approximately 5.5h after administration of ATD, or placebo | |
Secondary | Associations with Personalities of subjects | Personalities of subjects will be measured by a series of scales related to decision making and social reward, such as the Sensitivity to Punishment and Sensitivity to Reward Questionnaire (SPSRQ), which measures participants' sensitivity to reward and punishment. SPSRQ is a self-reported instrument that includes 48 yes/no questions divided into two subscales: Sensitivity to Reward (SR, 24 items, ranging from 0 (insensitive) to 24 (sensitive) to reward) and Sensitivity to Punishment (SP, 24 items, ranging from 0 (insensitive) to 24 (sensitive) to punishment). Associations between individual differences in personalities of subjects and differences in behaviors will be measured. | before 30mins ATD or placebo administration | |
Secondary | Behavioral performance in decision making task | Behavioral performance in reversal learning task will be measured and compared between treatment groups. | approximately 4h after administration of ATD, or placebo, before nasal spray | |
Secondary | Behavioral performance in social reward related task | Behavioral performance will be measured and compared between treatment groups | approximately 105 minutes after intranasal administration of oxytocin, or placebo, approximately 6.5h after administration of ATD, or placebo |
Status | Clinical Trial | Phase | |
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