The Neural Representation of Self in Depression Patients

Healthy Clinical Trial

Official title:

The Different Neural Representation of Self in Depression Patients and Healthy Individuals.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03551041
• Other study ID #: DepressionSelf_fMRI
• Status: Completed
• Start date: May 27, 2014
• Est. completion date: January 26, 2018

Study information

• Verified date: February 2018
• Source: Beijing Normal University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

To be aware of oneself as a unique entity in the world occurs early in human development and is the prerequisite of normal social functioning. The disturbance of self representation characterizes a variety of mental disorders such as autism and schizophrenia. Negative self-bias was found to serve as the core cognitive mechanism of depression disorder. However, there was no evidence to show the reason lead to negative bias. In the current study, investigators hypothesized that the blurring self representation was the neural correlates in depression disorder.

Description:

To test investigators' hypothesis, investigators adopted the self-referential task and fMRI to investigate the neural representation of self in depression patients, and compared with healthy control.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: January 26, 2018
• Est. primary completion date: June 15, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients should be clinical diagnosis of major depression disorder.

• Healthy control participants should be age-matched with depression group, and should have no history of neurological or psychiatric diagnoses

Exclusion Criteria:

• Patients who also have bipolar disorder, schizophrenia, anxiety disorder

• Healthy controls who have history of mental disorders

Related Conditions & MeSH terms

• Depression
• Depression Disorder
• Depressive Disorder
• Healthy

Locations

Country	Name	City	State
n/a

Sponsors (3)

Lead Sponsor	Collaborator
Beijing Normal University	Peking University, Southwest University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neural representation of self	We adopted the self referential task. In the task, participants were asked to judge whether a given word was appropriate to describe oneself (self-judgement condition), a celebrity (other-judgement condition) by pressing one of the two buttons with the index or middle finger. For judgments of each target person (i.e, self and celebrity), there were 3 categories of words describing the mental (personality traits, such as hard-working, friendly), physical (physical attributes, such as black hair, big eyes) and social (social roles, such as student, American) dimension of person knowledge. The fMRI task contained 6 runs, with 4.6 minutes per run.; This paradigm and task allowed us to investigated the neural representation of self by comparing the BOLD activity under self-judgement condition with BOLD activity under other-judgement condition.	through study completion, an average of 2 year