Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Healthy Clinical Trial

Official title:

Effect of Cherry Concentrate on Brain Activation and Perfusion in Healthy Older Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03547102
• Other study ID #: 115229/02
• Status: Completed
• Phase: N/A
• Start date: January 2016
• Est. completion date: December 2016

Study information

• Verified date: June 2018
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Effect of 8 weeks of cherry concentrate supplementation on cognitive function and brain perfusion in healthy older adults

Description:

The investigators will perform a double blind, randomised controlled study to determine whether cherry polyphenols improve peripheral vascular function and cerebral perfusion resulting in improved task related brain activation and cognitive function. 30 healthy elderly men and women 60-85y years will be recruited to complete 8-week supplementation with MC concentrate or an isoenergetic cherry placebo concentrate. Participants will be pair matched for age, sex, and cognitive function (Adenbrooke's Cognitive Examination III, ACE-III) and then randomised using a sealed envelope system to receive either placebo or cherry.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: December 2016
• Est. primary completion date: May 2016
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years to 80 Years

Eligibility

Inclusion Criteria:

• physically inactive consuming 5 or less portions of fruit per day Addenbrookes cognitive examination III score >88

Exclusion Criteria:

• physically active consuming more than 5 portions of fruit per day Addenbrookes cognitive examination III score <88 Contraindications for MRI

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• Cherry concentrate

• Placebo concentrate

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain perfusion	Arterial spin labelling using MRI, measure will be reported as ml/min	Change from baseline to 8 weeks supplementation
Secondary	Cognitive function	Battery of cognitive function tasks assessing executive function, global cognitive function score will be reported	Change from baseline to 8 weeks supplementation
Secondary	Brain activation (fMRI)	fMRI using a hippocampal biased task	Change from baseline to 8 weeks supplementation
Secondary	Plasma nitrite concentration	Plasma sample analysed via chemiluminescence technique	Change from baseline to 8 weeks supplementation