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Lung Pharmacokinetics (PK) in Epithelial Lining Fluid (ELF)

Healthy Clinical Trial

Official title:
Understanding the Lung Pharmacokinetics (PK) in Humans by Direct Sampling of Epithelial Lining Fluid (ELF) After Inhalation and Oral Administration of Model Drugs

Clinical Trial Summary

The aim of the present study is to increase the general understanding of lung PK of selected compounds by sampling epithelial lining fluid ELF and lung tissue.

Clinical Trial Description

This study will investigate drug levels of selected compounds at multiple sites in the lung and explore different innovative sampling methods to obtain information on lung PK. The aim of the study is not to generate safety or efficacy data of the selected licensed drugs. The choice of drugs is based on general considerations regarding therapy of airway diseases and the physical-chemical properties of the compounds. It is not driven by the compounds per se. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03524066
Study type Interventional
Source Fraunhofer-Institute of Toxicology and Experimental Medicine
Contact
Status Completed
Phase N/A
Start date April 10, 2018
Completion date December 31, 2018
View Details
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