Healthy Clinical Trial
Official title:
Protein Requirements in Resistance Trained Females
NCT number | NCT03397043 |
Other study ID # | RTF |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | November 1, 2016 |
Est. completion date | November 30, 2018 |
Verified date | March 2019 |
Source | University of Toronto |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, the investigators will use the minimally invasive indicator amino acid oxidation (IAAO) technique to determine protein requirements in weight-trained males. It is hypothesized that the present study will show that protein requirements for weight-trained females are i) greater than the current RDA for non-active individual's comparable estimates, and ii) greater than existing nitrogen balance-based estimates for weight-training individuals
Status | Completed |
Enrollment | 8 |
Est. completion date | November 30, 2018 |
Est. primary completion date | October 6, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - healthy female weight-trained individuals that have trained consistently for >1 year - complete a physical activity readiness questionnaire (PAR-Q+) - Train each muscle group (i.e. chest, back, legs) at least twice a week - Meets strength relative to body weight GUIDELINES adapted from Morton et al., 2016; Chilibeck et al., 1997 (sex specific). Bench Press: body weight (kg)*0.7 Leg Press: body weight (kg)*2.3 Exclusion Criteria: - sedentary for greater than 1 month in the last 6 months prior to the study - non-weight stable for the past month - smoker - Illicit drug use (e.g. growth hormone, testosterone, etc.) - Individual plans to increase or decrease body mass in the next 3 months - Habitually ingests greater than or equal to 3g protein kg/bw/day - Use of supplements such as creatine and beta-alanine in the last 30 days. - Hormone-based birth control. Hormonal fluctuations associated with the menstrual cycle have been reported to alter protein metabolism during exercise (Hamadeh, Devries, and Tarnopolsky, 2005) For this reason, the following exclusion criteria will be applied to female participants only: use of birth control and discontinued use within last 3 months - Inability to adhere to any of the protocol guidelines |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
University of Toronto |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Phenylalanine oxidation | In µmol/kg/h, the product of F13CO2 and VCO2. F13CO2 is determined via breath enrichment analysis of 13CO2 after 1-13C phenylalanine ingestion, and VCO2 is determined via indirect calorimetry | Through study completion: an average of 6 metabolic trials (days), each separated by approximately 1 week | |
Secondary | Phenylalanine rate of appearance | In µmol/kg/h; calculated from urine analysis of1-13C Phe enrichment | Through study completion: an average of 6 metabolic trials (days), each separated by approximately 1 week | |
Secondary | Net protein balance | In µmol/kg/h; calculated as the difference between whole body net protein synthesis and protein breakdown | Through study completion: an average of 6 metabolic trials (days), each separated by approximately 1 week |
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