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Clinical Trial Summary

The aim of the study is to investigate the effect of losartan (50mg, single dose) on the extinction of conditioned fear


Clinical Trial Description

In a double-blind, between-subject, placebo controlled design the effects of a single dose of losartan (50mg) on fear extinction in healthy male participants will be examined. Participants will initially undergo a Pavlovian fear conditioning procedure, followed by the administration of 50mg losartan or placebo. 90 minutes after treatment subjects will undergo the fear extinction procedure. Neural activity and psychophysiological indices of arousal will be assessed by the simultaneous acquisition of functional magnetic resonance imaging (fMRI) and skin conductance data. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03396523
Study type Interventional
Source University of Electronic Science and Technology of China
Contact Weihua Zhao, Master
Phone 86-28-61830811
Email zarazhao.uestc@outlook.com
Status Recruiting
Phase N/A
Start date January 4, 2018
Completion date December 31, 2018

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