Healthy Clinical Trial
Official title:
CirculAting Bile Acids as Biomarkers of Metabolic Health - Linking microbiotA, Diet and Health
During digestion of fatty foods, the liver produces a substance called bile which helps with
the absorption of fat in the gut (small intestine). Some research studies have shown that
friendly bacteria that live in our gut can change the makeup of bile (referred to as bile
acids) leading to a lowering of blood cholesterol levels, an important risk factor for
developing heart disease. This finding has been found in people who consume diets high in
dietary fibers and probiotics that enhance the growth of friendly gut bacteria, and also
plant rich foods high in polyphenols (such as apples). At present, very little is known about
how the makeup of bile acids can regulate blood cholesterol levels and if their measurement
in blood, urine or stool samples can be used as an indicator of human health.
The aim of this study is to explore how consumption of foods which enhance the growth of
friendly gut bacteria (such as probiotics, prebiotics, and plant rich foods high in
polyphenols) can change the makeup of bile acids after 8 weeks. Changes in the bile acids
measured in blood and stool samples will then be related to markers of health, such as blood
cholesterol, glucose, insulin, vascular health and inflammatory markers.
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