Healthy Clinical Trial
Official title:
Absorption, Metabolism and Excretion of Dietary Polyphenolic Bioactives in Humans
The objectives of this study are to i) describe the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetic parameters of selected dietary (poly)phenols in humans; and ii) to compare the ADME and pharmacokinetic parameters of selected dietary (poly)phenols in humans.
Dietary (poly)phenols are a large group of bioactive food constituents that can be classified
in flavonoids, stilbenes, lignans and phenolic acids. Flavonoids can be subclassified in
different subgroups, including but not limited to flavanols (e.g. (−)-epicatechin,
(+)-catechin, procyanidins, EGCG, EGC, etc) and flavones (apigenin and luteolin). Examples of
flavanol-containing foods and beverages are apples, chocolate, tea, wine, berries,
pomegranate and nuts. Examples of flavone-containing foods and beverages are parsley, celery,
and chamomile.
(Poly)phenolic bioactives are actively investigated for their putative beneficial health
effects in humans. In this context, understanding the ADME of dietary (poly)phenols is
recognized as a key step to gain insight into the nutritional and biomedical relevance of
this group of compounds. Understanding the ADME of polyphenols may aid towards i) the
identification of metabolites as potential nutritional biomarkers of (poly)phenol
consumption, ii) the identification of potential active metabolites mediating the effects
observed after (poly)phenol intake, and iii) the design and execution of dietary intervention
studies aiming at assess safety and efficacy of (poly)phenols.
Over the last years, significant progress has been made on the description of the ADME of
certain (poly)phenols. The investigators recently described the ADME of (−)-epicatechin.
However, there is still need to understand the ADME of other polyphenolic bioactives as well
as the importance of the role of the gut microbiome in the metabolism of these compounds. In
this context, the investigators aim at describing and comparing the ADME of dietary
polyphenolic bioactives in humans. To accomplish this, the investigators propose conducting a
randomized, double-masked and cross-over dietary intervention study in healthy young adult
males. The investigators will evaluate the concentration of polyphenol-derived metabolites in
plasma and urine after single acute intakes of polyphenol-containing test materials on 8
different test days.
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