Healthy Clinical Trial
Official title:
Evaluation of a New Method for Measuring Stool Consistency, Using a Texture Analyser (TA.XT Express Texture Analyser)
This study is designed to validate a new direct method for the measurement of stool consistency, using Texture Analyser. Forty healthy subjects are enrolled in this trial for collection of stool samples. Every stool produced during 2 collection periods of approximately 60 hours each is collected and subjected to the measurement of consistency using Texture Analyser. The stool consistency results are compared with the Bristol Stool Form Scale scores for each stool. The relationships of stool consistency with other stool parameters, bowel habit and sleeping habit are also evaluated.
It is now obvious that the proper functioning of the gastrointestinal tract has a positive
effect on the quality of life. Normal bowel habits vary considerably from person to person
with regard to frequency of bowel movements, and bulk and consistency of stools. Constipation
is the common digestive complaint in European populations, and softening stool consistency
can be regarded as beneficial for such population in terms of reducing incidence of hard or
lumpy stools .
The Bristol Stool Form Scale (BS) is validated as a surrogate measure for gastrointestinal
transit time, and has been also applied to an evaluation of stool consistency. Subjects
compare their stool with the BS chart consisting of seven categories and choose one score
which has a nearest analog form. The BS has been widely used in the studies to evaluate
changes in stool consistency after dietary intervention using probiotics and/or prebiotics.
However, there is a lack of evidence in the validity of BS to yield consistent and
reproducible estimates of changes in stool consistency over time. In order to obtain a closer
estimate of its change, it would be preferred to use a more directly observable and objective
parameter or combination of parameters.
From the above mentioned backgrounds, this study is conducted to validate a new direct method
for the measurement of stool consistency, using Texture Analyser: TA.XTExpress Texture
Analyser (Stable Micro Systems Ltd.).
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