Healthy Clinical Trial
Evaluation of a New Method for Measuring Stool Consistency, Using a Texture Analyser (TA.XT Express Texture Analyser)
|Source||Yakult Honsha European Research Center, ESV|
|Status||Enrolling by invitation|
|Start date||June 2, 2017|
|Completion date||September 30, 2017|
This study is designed to validate a new direct method for the measurement of stool consistency, using Texture Analyser. Forty healthy subjects are enrolled in this trial for collection of stool samples. Every stool produced during 2 collection periods of approximately 60 hours each is collected and subjected to the measurement of consistency using Texture Analyser. The stool consistency results are compared with the Bristol Stool Form Scale scores for each stool. The relationships of stool consistency with other stool parameters, bowel habit and sleeping habit are also evaluated.
It is now obvious that the proper functioning of the gastrointestinal tract has a positive
effect on the quality of life. Normal bowel habits vary considerably from person to person
with regard to frequency of bowel movements, and bulk and consistency of stools.
Constipation is the common digestive complaint in European populations, and softening stool
consistency can be regarded as beneficial for such population in terms of reducing incidence
of hard or lumpy stools .
The Bristol Stool Form Scale (BS) is validated as a surrogate measure for gastrointestinal transit time, and has been also applied to an evaluation of stool consistency. Subjects compare their stool with the BS chart consisting of seven categories and choose one score which has a nearest analog form. The BS has been widely used in the studies to evaluate changes in stool consistency after dietary intervention using probiotics and/or prebiotics. However, there is a lack of evidence in the validity of BS to yield consistent and reproducible estimates of changes in stool consistency over time. In order to obtain a closer estimate of its change, it would be preferred to use a more directly observable and objective parameter or combination of parameters.
From the above mentioned backgrounds, this study is conducted to validate a new direct method for the measurement of stool consistency, using Texture Analyser: TA.XTExpress Texture Analyser (Stable Micro Systems Ltd.).
|Terminated||NCT00001844 - Study of New Magnetic Resonance Methods||N/A|
|Completed||NCT02235961 - Investigate Safety, Tolerability and Pharmacokinetics for Single Doses of NNC9204-0530 Alone and in Combination With Liraglutide in Overweight to Obese But Otherwise Healthy Male Subjects||Phase 1|
|Completed||NCT00527579 - PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [F-18]FB||Phase 1|
|Completed||NCT00526916 - PET Imaging of Peripheral Benzodiazepine Receptors in Patients With Neurocysticercosis Using [C-11]PBR28||Phase 1|
|Recruiting||NCT02509494 - Staged Phase 3 Study to Assess the Safety and Immunogenicity of Ebola Candidate Vaccines Ad26.ZEBOV and MVA-BN-Filo During Implementation of Stages 1 and 2||Phase 3|
|Terminated||NCT02555085 - Single Ascending Doses of BIIB063 in Healthy Volunteers||Phase 1|
|Completed||NCT03125018 - Accuracy of SpO2 for Noninvasive Pulse Oximeter Sensor (LNCS ADTX)||N/A|
|Completed||NCT03124901 - Accuracy of Noninvasive Pulse Oximeter Measurement of Hemoglobin for Rainbow DCI Sensor||N/A|
|Completed||NCT00091533 - Neural Correlates of Observation of Tactile Stimulation in Healthy Subjects||N/A|
|Completed||NCT00068926 - VRC 300: Screening of Healthy Volunteers for Clinical Trials of Investigational Vaccines to Prevent Infectious Diseases||N/A|
|Completed||NCT02947139 - Drug-Drug Interaction Study Between DWC20155 / DWC20156 and DWC20161 in Healthy Volunteers||Phase 1|
|Completed||NCT00538798 - PET Imaging of Brain mGluR5 Receptors Using [18F]SP203||Phase 1|
|Completed||NCT00097461 - Revising Employee Benefits for the Sake of Health||N/A|
|Completed||NCT00001936 - Electrical Muscle Stimulation to Aid Swallowing in Dysphagia||N/A|
|Completed||NCT00004556 - The Effects of Dextroamphetamine on Brain Function||N/A|
|Recruiting||NCT03119909 - Cognitive Adaptation||N/A|
|Completed||NCT03179345 - Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica||Phase 4|
|Completed||NCT02911870 - A Thorough QTc Trial Evaluating the Effect of SNAC on Cardiac Repolarisation in Healthy Male Subjects||Phase 1|
|Completed||NCT03056898 - Health Professional Dietary Habits and Blood Omega-3 Fatty Acid Concentrations||N/A|
|Completed||NCT02543567 - A Study to Evaluate A Range of Dose Levels of Ad26.ZEBOV and MVA‐BN‐Filo in Healthy Adult Participants||Phase 3|