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NCT ID: NCT03181217 Completed - Healthy Clinical Trials

Functional Magnetic Resonance Imaging of Human Hypothalamic Responses to Oral Temperature and Glucose Sensing

COLD
Start date: January 28, 2013
Phase: N/A
Study type: Interventional

The study will consist of four occasions with one week between the occasions. fMRI will be performed to monitor hypothalamic activity before and after an ingestion of 1 of the following 4 stimuli (300 ml of each): water at room temperature, water at 0 degrees Celsius, glucose solution at room temperature, glucose solution at 0 degrees Celsius. The last two stimuli both contain 75 gram glucose. The order of conditions will be randomly assigned to the subjects. Functional connectivity of the hypothalamic regions will be assessed by analysing the resting state fMRI.

NCT ID: NCT03180879 Active, not recruiting - Healthy Clinical Trials

Ibuprofen Bioavailability Study

Start date: April 10, 2017
Phase: Phase 1
Study type: Interventional

This project is the in-house development of a 200 mg ibuprofen acid orodispersable tablet (ODT; meltlet). It is designed to appeal to consumers who want a dosage form that may be taken without water and can be used 'on the go'. Vanquish has an improved organoleptic profile compared to the currently marketed meltet by the Sponsor. ODTs are also considered as a suitable dosage form for children who may be reluctant to swallow tablets. This product has the potential for application in both adults and children due to the convenience of the format and the ease of administration for both groups. This will be the first pharmacokinetic (PK) assessment of the ibuprofen acid ODT formulation.

NCT ID: NCT03180814 Not yet recruiting - Healthy Clinical Trials

Effects of Whole Body Vibration on Autonomic Function in Healthy Young and Elderly

Start date: June 2017
Phase: N/A
Study type: Interventional

Aging causes anatomical and physiological changes in the cardiovascular system and autonomic function with decline in its maximum function. This study aimed to evaluate the acute effects of whole body vibration on cardiovascular system, autonomic function and heart variability in healthy young and elderly. The investigators' hypothesis is that whole body vibration has different effects in young and elderly.

NCT ID: NCT03180762 Recruiting - Healthy Clinical Trials

A Study to Investigate Safety and Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-64140284 in Healthy Participants

Start date: May 30, 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of JNJ-64140284 versus placebo after single oral dose administration (ascending dose levels) under fasted condition, to characterize the pharmacokinetics (PK) of JNJ-64140284 in plasma, cerebrospinal fluid (CSF) and urine after single oral dose administration and to investigate the effect of food (high fat/high calorie) on the PK of JNJ-64140284 following single oral dose administration.

NCT ID: NCT03180242 Completed - Healthy Clinical Trials

A Pharmacokinetic Study Comparing EG12014 and Herceptin (Trastuzumab) in Healthy Male Volunteers

Start date: March 22, 2016
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to assess the pharmacokinetic similarity of EG12014 (Test IMP) compared to reference products sourced from the European Union (Reference IMP 1: Herceptin® 150 mg powder for concentrate for solution for infusion) and the United States (Reference IMP 2: Herceptin® 440 mg powder for concentrate for solution for infusion) after intravenous infusion over 90 minutes of a single dose of 6 mg/kg trastuzumab in 3 parallel groups of healthy male subjects.

NCT ID: NCT03179345 Completed - Healthy Clinical Trials

Simulated Driving Performance, Daytime Sedation and Cognition in Healthy Volunteers Taking Gralise, Neurontin or Lyrica

Start date: September 24, 2015
Phase: Phase 4
Study type: Interventional

Phase 4, double-blind, placebo-controlled, four treatment, four sequence crossover study comparing simulated driving performance, daytime sedation and cognition in healthy volunteers administered therapeutic doses of Gralise® (Treatment A), Neurontin® (Treatment B), Lyrica® (Treatment C) and placebo (Treatment D). All doses were administered under fed conditions.

NCT ID: NCT03178396 Completed - Healthy Clinical Trials

Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets

Start date: December 7, 2015
Phase: N/A
Study type: Interventional

The investigators will be studying the effect of melatonin on blood pressure, insulin resistance, and platelets, along with possible reasons for how melatonin cases these effects.

NCT ID: NCT03178344 Not yet recruiting - Healthy Clinical Trials

Effect of tACS Stimulation on Stress

AIMS1
Start date: June 2017
Phase: N/A
Study type: Interventional

Transcranial Alternating Current Stimulation (tACS) is one method that has been demonstrated to enhance alpha oscillations in healthy participants by applying weak electrical currents to the scalp to modulate rhythmic brain activity patterns. Analysis of results from other studies involving tACS indicate that the response to stimulation is gated by stress, previously measured using heart rate variability, pupil diameter, and respiration. Therefore, this study will involve tACS-induced frontal alpha oscillations, EEG recordings, and more detailed physiological markers of stress in order to further explore this relationship.

NCT ID: NCT03175614 Recruiting - Healthy Clinical Trials

Impact of the Usefulness of ICTs on the Increase of Physical Activity and Weight Loss in Obese and Sedentary People.

EVIDENT3
Start date: June 1, 2017
Phase: N/A
Study type: Interventional

This is a randomized clinical trial aimed at obese and sedentary subjects aged 20 to 65 years selected in urban primary care centers of 5 centers (Spain). Its objective is to evaluate the effects of the addition of an ICT tool developed for the Smartphone application and a Smartband in support of behavioral and educational recommendations to reduce weight.

NCT ID: NCT03175484 Not yet recruiting - Healthy Clinical Trials

Simulation to Assess Cognitive Workload and Task Load IndeX (TLX) Performance

Start date: June 1, 2017
Phase: N/A
Study type: Observational

High-fidelity simulation (HFS) is a learning method extensively used for training of surgical specialty (including anesthesia) and nurses. It has a beneficial effect on knowledge of algorithms, team working, early warning scores, and communication. Various skills can be learned using a standardized simulation programs. The complexity of instructional design may produce cognitive overload, high stress level and anxiety. This may increase fatigue, facilitate errors, and is associated with inferior task performance which may impede memorization of learned skills resulting in inefficient learning/simulation failure. Subjectively reported scales can accurately identify the level of perceived workload and mental demand in individuals during simulation tasks. One example is the National Aeronautics and Space Administration (NASA)-TLX - the most accepted subjective measure of human workload in various industries including medicine. Surgical specialty (including anesthesia) and nurses training curriculum in Lyon, France, includes several HFS scenarios with a large panel of critical events. The investigators aim to evaluate the effect of burden of workload and stress perceived by surgical specialty (including anesthesia) residents and nurses during HFS on the learning performance, and to grade different learning scenarios by their difficulty.