Evaluation of the Ketogenic Potential of Different Diet Supplements

Healthy Adults Clinical Trial

Official title:

Stimulating the Ketogenesis by Using Nutritional Supplements

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02693106
• Other study ID #: 2014-387
• Status: Completed
• Phase: N/A
• Start date: July 2013
• Est. completion date: June 2015

Study information

• Verified date: March 2020
• Source: Université de Sherbrooke
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Evaluate the capacity of different dietary supplements to increase ketone production in healthy adults.

Description:

The aim of this study is to evaluate the capacity of different dietary supplements to increase ketone production in healthy adults. Each supplement (leucine, butyrate, octanoate, carnitine or butter fraction rich in MCT) is evaluated for a period of 4-hour during which multiple blood samples are taken in order to measure ketone production.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: June 2015
• Est. primary completion date: June 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Healthy adults aged of 18 years old or older.

• Non-smoking.

Exclusion Criteria:

• Diabetes or prediabetes

• Uncontrolled hypertension

• Uncontrolled thyroid function

• Taking medication that will affect lipid/glucose metabolism

• Severe infection or inflammation

• Pregnancy

Related Conditions & MeSH terms

• Healthy Adults

Intervention

Dietary Supplement:
• Control
Visit corresponding to a standardize breakfast taken alone (control visit) followed by a period of 4-hour with multiple blood sampling.
• Leucine
Visit corresponding to a standardize breakfast with 5 g of leucine followed by a period of 4-hour with multiple blood sampling.
• Butyrate -
Visit corresponding to a standardize breakfast with 3.6 g of butyrate followed by a period of 4-hour with multiple blood sampling.
• Butyrate +
Visit corresponding to a standardize breakfast with 7.2 g of butyrate followed by a period of 4-hour with multiple blood sampling.
• Octanoate -
Visit corresponding to a standardize breakfast with 5 g of octanoate followed by a period of 4-hour with multiple blood sampling.
• Octanoate +
Visit corresponding to a standardize breakfast with 10 g of octanoate followed by a period of 4-hour with multiple blood sampling.
• Carnitine
Visit corresponding to a standardize breakfast with 1.95 g of carnitine followed by a period of 4-hour with multiple blood sampling.
• Butter fraction
Visit corresponding to a standardize breakfast with 65 g of butter fraction followed by a period of 4-hour with multiple blood sampling.

Locations

Country	Name	City	State
Canada	Research Centre on Aging (CSSS-IUGS - CIUSSS de l'Estrie - CHUS)	Sherbrooke	Quebec

Sponsors (1)

Lead Sponsor	Collaborator
Université de Sherbrooke

Country where clinical trial is conducted

Canada, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Concentration of Total Plasma Ketones	Difference from Time 0 in Total ketones = acetoacetate (umol/L) + beta-hydroxybutyrate (umol/L) Time 0 is when the participants arrived, after a 12 hours fast, i.e. before the breakfast.; Plasma was collected every 30 minutes for 4 hours immediately following breakfast (where supplements were taken).; Results are the mean of plasma ketones measured every 30 minutes ( i.e. total of 9 plasma samples) for the 4 hour period.; For each time point, the difference form time 0 has been made. So this is the mean of the difference from time 0 in total ketones.; Data were not collected for the 'Intervention 8: 65 g of butter fraction rich in MCT' supplement.	4 hours