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The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects

Headache Clinical Trial

Official title:
The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects

Clinical Trial Summary

Studying Pituitary adenylate cyclase-activating peptide 38 (PACAP38) induced headache effects on extra- and intracerebral arteries and pre-posttreated by sumatriptan and ketorolac assessed by magnetic resonance imaging (MRI) on healthy volunteers.

Clinical Trial Description

The purpose of this research project is to investigate the importance of blood vessel (vasodilatation), vessel wall inflammation and blood flow in arteries of headaches triggered by PACAP38 and for headache treated with sumatriptan (migraine medicine) and ketorolac (NSAID). In addition, we will investigate headache-related changes in the brain's network connectivity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03585894
Study type Interventional
Source Danish Headache Center
Contact
Status Completed
Phase N/A
Start date August 1, 2018
Completion date November 25, 2019
View Details
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